Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 2/20 | 0.37 |
| ▸ | PDE4A | P27815 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 3/20 | 0.34 |
| ▸ | P2RX3 | P56373 | 4/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8564881 | 0.87 | PDE4A (0.38) | PDE4AMEN1KMT2APDE4BPDE4C | |
| SCHEMBL8558380 | 0.79 | HPGD (0.40) | PDE4APDE4BPDE4CPDE4DTACR1 | |
| SCHEMBL8561168 | 0.79 | PDE4A (0.40) | PDE4APDE4BPDE4CPDE4DTACR1 | |
| SCHEMBL8561220 | 0.78 | MEN1 (0.39) | PTAFRMEN1KMT2APDE4DKDM4C | |
| Hydrochloric Acid SCHEMBL8593049 | 0.71 | CCR3 (0.42) | MEN1KMT2ATACR1 | |
| SCHEMBL8707339 | 0.71 | TACR1 (0.43) | PDE4AMEN1KMT2APDE4BPDE4C | |
| SCHEMBL7846541 | 0.71 | TACR1 (0.60) | TACR1 | |
| SCHEMBL8291780 | 0.71 | KCNH2 (0.48) | PTAFRMEN1KMT2A | |
| SCHEMBL4631281 | 0.69 | TACR1 (0.45) | TACR1 | |
| SCHEMBL8300796 | 0.69 | TACR1 (0.59) | TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5807865-A | 3,3-disubstituted piperidine derivatives and their use as therapeutic agents | MERCK SHARP & DOHME LIMITED (GB) | 1998-09-15 | — | — | US | disclosed |