Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.70 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.58 |
| ▸ | MAOB | P27338 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | DPP4 | P27487 | 1/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8558008 | 0.98 | LMNA (0.69) | LMNAHSD17B10HDAC1KMT2AHDAC8 | |
| SCHEMBL8559273 | 0.96 | LMNA (0.71) | LMNAHSD17B10HDAC1KMT2AHDAC8 | |
| SCHEMBL2354530 | 0.92 | LMNA (0.77) | LMNAHSD17B10HDAC1KMT2AHDAC8 | |
| SCHEMBL17457887 | 0.92 | HSD17B10 (0.74) | LMNAHSD17B10KMT2AMAPTALDH1A1 | |
| SCHEMBL11424105 | 0.87 | HSD17B10 (0.74) | LMNAHSD17B10KMT2AHDAC8MAPT | |
| SCHEMBL7741913 | 0.86 | MAPT (0.70) | LMNAHSD17B10HDAC1KMT2AMAOB | |
| SCHEMBL11727340 | 0.85 | L3MBTL1 (0.72) | KMT2AMAOBSMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL2212719 | 0.85 | HSD17B10 (0.89) | LMNAHSD17B10HDAC1KMT2AHDAC8 | |
| SCHEMBL7825556 | 0.84 | HSD17B10 (0.70) | LMNAHSD17B10KMT2AHDAC8MAPT | |
| SCHEMBL9258997 | 0.84 | HSD17B10 (0.65) | LMNAHSD17B10KMT2AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5843997-A | Excitatory amino acid receptor antagonists | ELI LILLY AND COMPANY (US) | 1998-12-01 | — | — | US | disclosed |
| US-5576323-A | CENTRAL NERVOUS SYSTEM DISORDERS | ELI LILLY AND COMPANY (US) | 1996-11-19 | — | — | US | disclosed |
| EP-0658539-A1 | Excitatory amino acid receptor antagonists | ELI LILLY AND COMPANY (US) | 1995-06-21 | — | — | EP | disclosed |