Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | AHR | P35869 | 4/20 | 0.37 |
| ▸ | MMP12 | P39900 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8559691 | 0.86 | GAA (0.41) | MAPTMEN1KMT2AKDM4ENPC1 | |
| SCHEMBL8561609 | 0.81 | GAA (0.62) | MAPTMEN1KMT2AKDM4ENPC1 | |
| SCHEMBL9266525 | 0.78 | GAA (0.67) | MAPTMEN1KMT2AKDM4ENPC1 | |
| SCHEMBL9262051 | 0.72 | GAA (0.62) | MAPTMEN1KMT2AGAAHSD17B10 | |
| SCHEMBL16852147 | 0.70 | GAA (0.44) | MAPTMEN1KMT2AKDM4ENPC1 | |
| SCHEMBL8562293 | 0.69 | GAA (0.40) | MAPTMEN1KMT2AKDM4ENPC1 | |
| SCHEMBL15046597 | 0.69 | ALDH1A1 (0.50) | MAPTKMT2AGAAALDH1A1HSD17B10 | |
| SCHEMBL8560344 | 0.69 | GAA (0.67) | MAPTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL8559100 | 0.67 | GAA (0.54) | MAPTMEN1KMT2AKDM4ENPC1 | |
| SCHEMBL11538460 | 0.67 | GAA (0.42) | MAPTMEN1KMT2AKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640592-B1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID CO (US) | 1998-12-30 | — | — | EP | disclosed |
| EP-0640592-A1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID COMPANY (US) | 1995-03-01 | — | — | EP | disclosed |