Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 14/20 | 0.67 |
| ▸ | MAOB | P27338 | 1/20 | 0.65 |
| ▸ | HRH2 | P25021 | 1/20 | 0.62 |
| ▸ | HRH1 | P35367 | 1/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.59 |
| ▸ | HTR3A | P46098 | 2/20 | 0.58 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.58 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.58 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1178972 | 1.00 | HRH3 (0.67) | HRH3MAOBHRH2HRH1KCNH2 | |
| SCHEMBL1179056 | 1.00 | HRH3 (0.67) | HRH3MAOBHRH2HRH1KCNH2 | |
| SCHEMBL1776447 | 0.96 | HRH3 (0.71) | HRH3MAOBHRH2HRH1KCNH2 | |
| SCHEMBL1179009 | 0.96 | HRH3 (0.62) | HRH3MAOBHRH2HRH1KCNH2 | |
| SCHEMBL1775252 | 0.96 | HRH3 (0.62) | HRH3MAOBHRH2HRH1KCNH2 | |
| SCHEMBL1776848 | 0.93 | HRH3 (0.57) | HRH3MAOBHRH2HRH1KCNH2 | |
| SCHEMBL1178719 | 0.93 | HRH3 (0.57) | HRH3MAOBHRH2HRH1KCNH2 | |
| SCHEMBL4467743 | 0.86 | HRH3 (0.67) | HRH3MAOBHRH2HRH1KCNH2 | |
| SCHEMBL1372942 | 0.86 | HRH3 (0.67) | HRH3MAOBHRH2HRH1KCNH2 | |
| SCHEMBL4562819 | 0.86 | HRH3 (0.67) | HRH3MAOBHRH2HRH1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160095848-A1 | PHENYLPYRROLE DERIVATIVE | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2016-04-07 | — | — | US | disclosed |
| US-9284324-B2 | Phenylpyrrole derivative | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2016-03-15 | — | — | US | disclosed |
| US-20150045553-A1 | PHENYLTRIAZOLE DERIVATIVE | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2015-02-12 | — | — | US | disclosed |
| US-20140330010-A1 | PHENYLPYRROLE DERIVATIVE | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2014-11-06 | — | — | US | disclosed |
| EP-2799436-A1 | PHENYLTRIAZOLE DERIVATIVE | Taisho Pharmaceutical Co., Ltd. (JP) | 2014-11-05 | — | — | EP | disclosed |
| EP-2789608-A1 | PHENYLPYRROLE DERIVATIVE | Taisho Pharmaceutical Co., Ltd. (JP) | 2014-10-15 | — | — | EP | disclosed |
| EP-2221298-B1 | PHENYLPYRAZOLE DERIVATIVES | TAISHO PHARMACEUTICAL CO LTD (JP) | 2013-11-06 | — | — | EP | disclosed |
| EP-2221298-B1 | PHENYLPYRAZOLE DERIVATIVES | TAISHO PHARMACEUTICAL CO LTD (JP) | 2013-11-06 | — | — | EP | disclosed |
| EP-1945206-B1 | INDOLE DERIVATIVES AS HISTAMINE 3 RECEPTOR INHIBITORS FOR THE TREATMENT OF COGNITIVE AND SLEEP DISORDERS, OBESITY AND OTHER CNS DISORDERS | ATHERSYS INC (US) | 2013-04-24 | — | — | EP | disclosed |
| US-8193176-B2 | Phenylpyrazole derivatives | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2012-06-05 | — | — | US | disclosed |
| US-20090036446-A1 | Indole derivatives as histamine 3 receptor inhibitors for the treatment of cognitive and sleep disorders, obesity and other CNS disorders | BENNANI YOUSSEF L | 2009-02-05 | — | — | US | disclosed |
| US-20090036446-A1 | Indole derivatives as histamine 3 receptor inhibitors for the treatment of cognitive and sleep disorders, obesity and other CNS disorders | BENNANI YOUSSEF L | 2009-02-05 | — | — | US | disclosed |
| US-20090023708-A1 | Compounds Comprising a Lactam or a Lactam Derivative Moiety, Processes for Making Them, and Their Uses | UCB PHARMA, S.A. (BE) | 2009-01-22 | — | — | US | disclosed |
| EP-1610786-B9 | 4-(4-(HETEROCYCLYLALKOXY PHENYL)-1-(HETEROCYCLYL-CARBONYL)PIPERIDINE DERIVATIVES AND RELATED COMPOUNDS AS HISTAMINE H3 ANTAGONISTS FOR THE TREATMENT OF NEUROLOGICAL DISEASES SUCH AS ALZHEIMER'S | GLAXO GROUP LTD (GB) | 2008-02-27 | — | — | EP | disclosed |
| US-20070161676-A1 | Indole derivatives as histamine 3 receptor inhibitors for the treatment of cognitive and sleep disorders, obesity and other CNS disorders | ATHERSYS, INC. | 2007-07-12 | — | — | US | disclosed |
| US-20070161676-A1 | Indole derivatives as histamine 3 receptor inhibitors for the treatment of cognitive and sleep disorders, obesity and other CNS disorders | ATHERSYS, INC. | 2007-07-12 | — | — | US | disclosed |
| EP-1610786-B1 | 4-(4-(HETEROCYCLYLALKOXY PHENYL)-1-(HETEROCYCLYL-CARBONYL)PIPERIDINE DERIVATIVES AND RELATED COMPOUNDS AS HISTAMINE H3 ANTAGONISTS FOR THE TREATMENT OF NEUROLOGICAL DISEASES SUCH AS ALZHEIMER'S | GLAXO GROUP LTD (GB) | 2007-06-20 | — | — | EP | disclosed |
| US-20060205774-A1 | 4-(4-(Heterocyclylakoxy) phenyl-1-(heterocyclyl-carbonyl) piperidine derivavites and related compounds as histamine h3 antagonists for the treatment of neurological diseases such as alzheimer's | GLAXO GROUP LIMITED (GB) | 2006-09-14 | — | — | US | disclosed |
| EP-1610786-A1 | 4-(4-(HETEROCYCLYLALKOXY PHENYL)-1-(HETEROCYCLYL-CARBONYL)PIPERIDINE DERIVATIVES AND RELATED COMPOUNDS AS HISTAMINE H3 ANTAGONISTS FOR THE TREATMENT OF NEUROLOGICAL DISEASES SUCH AS ALZHEIMER'S | GLAXO GROUP LIMITED (GB) | 2006-01-04 | — | — | EP | disclosed |
| WO-2004089373-A1 | 4- (4-(HETEROCYCLYLALKOXY}PHENYL)-1-(HETEROCYCLYL-CARBONYL)PIPERIDINE DERIVATIVES AND RELATED COMPOUNDS AS HISTAMINE H3 ANTAGONISTS FOR THE TREATMENT OF NEUROLOGICAL DISEASES SUCH AS ALZHEIMER’S | GLAXO GROUP LIMITED (GB) | 2004-10-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090036446-A1 | Indole derivatives as histamine 3 receptor inhibitors for the treatment of cognitive and sleep disorders, obesity and other CNS disorders | HRH3, HCRTR1, HCRTR2 | HRH3 1/4885MAOB 211/4885HRH2 12/4885 |
| US-20150045553-A1 | PHENYLTRIAZOLE DERIVATIVE | PER2, BACE1, MAPT | HRH3 56/4885MAOB 87/4885HRH2 260/4885 |
| US-20160095848-A1 | PHENYLPYRROLE DERIVATIVE | PER2, CRY1, APP | HRH3 40/4885MAOB 101/4885HRH2 115/4885 |
| US-20060205774-A1 | 4-(4-(Heterocyclylakoxy) phenyl-1-(heterocyclyl-carbonyl) piperidine derivavites and related compounds as histamine h3 antagonists for the treatment of neurological diseases such as alzheimer's | HRH3, HRH4, HRH1 | HRH3 1/4885MAOB 92/4885HRH2 4/4885 |
| US-20090023708-A1 | Compounds Comprising a Lactam or a Lactam Derivative Moiety, Processes for Making Them, and Their Uses | COASY, FURIN, PEPD | HRH3 3883/4885MAOB 336/4885HRH2 2467/4885 |
| US-20140330010-A1 | PHENYLPYRROLE DERIVATIVE | PER2, CRY1, APP | HRH3 40/4885MAOB 101/4885HRH2 115/4885 |
| US-20070161676-A1 | Indole derivatives as histamine 3 receptor inhibitors for the treatment of cognitive and sleep disorders, obesity and other CNS disorders | HRH3, HCRTR1, HCRTR2 | HRH3 1/4885MAOB 211/4885HRH2 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.