Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 5/20 | 0.56 |
| ▸ | KDR | P35968 | 4/20 | 0.52 |
| ▸ | BRAF | P15056 | 3/20 | 0.52 |
| ▸ | FLT3 | P36888 | 3/20 | 0.52 |
| ▸ | KIT | P10721 | 2/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | HSPD1 | P10809 | 4/20 | 0.48 |
| ▸ | HSPE1 | P61604 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8563315 | 0.89 | KDR (0.51) | CTSDKDRBRAFFLT3KIT | |
| SCHEMBL8561560 | 0.84 | CTSD (0.55) | CTSDKDRBRAFFLT3KIT | |
| SCHEMBL8562462 | 0.81 | KDR (0.54) | KDRBRAFFLT3KITEGFR | |
| SCHEMBL8561654 | 0.80 | KDR (0.58) | CTSDKDRBRAFFLT3KIT | |
| SCHEMBL8561504 | 0.78 | KDR (0.50) | KDRBRAFFLT3KITEGFR | |
| SCHEMBL8559829 | 0.78 | CTSD (0.53) | CTSDKDRBRAFFLT3KIT | |
| SCHEMBL8566456 | 0.77 | KDR (0.58) | KDRBRAFFLT3KITEGFR | |
| SCHEMBL8562560 | 0.76 | BRAF (0.64) | KDRBRAFFLT3KITEGFR | |
| SCHEMBL8563685 | 0.76 | KDR (0.54) | KDRBRAFFLT3KITEGFR | |
| SCHEMBL8562810 | 0.74 | KDR (0.57) | KDRBRAFFLT3KITEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5814646-A | TREATING THE PROGRESSION OF ALZHEIMER'S DISEASE, BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 1998-09-29 | — | — | US | disclosed |
| US-5624937-A | TREATMENT OF ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY (US) | 1997-04-29 | — | — | US | disclosed |