Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.57 |
| ▸ | BRAF | P15056 | 9/20 | 0.57 |
| ▸ | FLT3 | P36888 | 4/20 | 0.57 |
| ▸ | KIT | P10721 | 2/20 | 0.57 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.40 |
| ▸ | TEK | Q02763 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.39 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8562560 | 0.81 | BRAF (0.64) | KDRBRAFFLT3KITEGFR | |
| SCHEMBL8563685 | 0.80 | KDR (0.54) | KDRBRAFFLT3KITEGFR | |
| SCHEMBL8561654 | 0.80 | KDR (0.58) | KDRBRAFFLT3KITEGFR | |
| SCHEMBL8562815 | 0.80 | KDR (0.49) | KDRBRAFFLT3KITEGFR | |
| SCHEMBL8875783 | 0.79 | ALDH1A1 (0.36) | KDRBRAFFLT3KITEGFR | |
| SCHEMBL8562462 | 0.77 | KDR (0.54) | KDRBRAFFLT3KITEGFR | |
| SCHEMBL8565704 | 0.76 | KDR (0.58) | KDRBRAFFLT3KITEGFR | |
| SCHEMBL8566456 | 0.74 | KDR (0.58) | KDRBRAFFLT3KITEGFR | |
| SCHEMBL8561563 | 0.74 | CTSD (0.56) | KDRBRAFFLT3KITEGFR | |
| SCHEMBL4555515 | 0.74 | LMNA (0.68) | KDRBRAFFLT3KITLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5814646-A | TREATING THE PROGRESSION OF ALZHEIMER'S DISEASE, BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 1998-09-29 | — | — | US | disclosed |