Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | PPM1B | O75688 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27550910 | 0.89 | MAPT (0.42) | MAPTPKMPPM1BPTPN1PPP1CC | |
| SCHEMBL7189528 | 0.89 | MAPT (0.42) | MAPTPKMPPM1BPTPN1PPP1CC | |
| SCHEMBL1417951 | 0.89 | MAPT (0.42) | MAPTPKMPPM1BPTPN1PPP1CC | |
| Acetic Acid SCHEMBL6729875 | 0.87 | MAPT (0.43) | MAPTPKMPPM1BPTPN1PPP1CC | |
| Hydrochloric Acid SCHEMBL2920606 | 0.87 | MAPT (0.44) | MAPTPKMPPM1BPTPN1PPP1CC | |
| Hydrochloric Acid SCHEMBL4283062 | 0.87 | MAPT (0.44) | MAPTPKMPPM1BPTPN1PPP1CC | |
| Chloroacetic Acid SCHEMBL27424329 | 0.83 | MAPT (0.40) | MAPTPKMPPM1BPTPN1PPP1CC | |
| Trifluoroacetic Acid SCHEMBL29935426 | 0.82 | PRCP (0.38) | SLC6A2SLC6A4SLC6A3PPM1BPTPN1 | |
| SCHEMBL27619781 | 0.79 | MAPT (0.40) | MAPTPKMSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL1951212 | 0.78 | PPM1B (0.37) | MAPTPKMPPM1BPTPN1PPP1CC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5849746-A | Substituted 1,4-piperazine-heteroaryl derivatives as 5-HT1D receptor agonists | MERCK SHARP & DOHME LTD. (GB) | 1998-12-15 | — | — | US | disclosed |