Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | NOS2 | P35228 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6677698 | 0.81 | NOTUM (0.57) | MAPK1ALDH1A1HSP90AA1MAPTRAB9A | |
| SCHEMBL27993916 | 0.78 | MAPK1 (0.48) | MAPK1BRD4HSP90AA1MAPTRAB9A | |
| SCHEMBL28126317 | 0.77 | MAPK1 (0.41) | MAPK1ALDH1A1NAMPT | |
| SCHEMBL28413210 | 0.76 | MAPK1 (0.47) | MAPK1BRD4HSP90AA1MAPTMEN1 | |
| SCHEMBL4880946 | 0.76 | BRD4 (0.45) | MAPK1BRD4ALDH1A1HSP90AA1MAPT | |
| SCHEMBL16268868 | 0.74 | ALDH1A1 (0.64) | MAPK1ALDH1A1MAPTRAB9AMEN1 | |
| SCHEMBL14149488 | 0.73 | MAPK1 (0.43) | MAPK1BRD4ALDH1A1MAPTMEN1 | |
| SCHEMBL3089343 | 0.73 | SMN1; SMN2 (0.46) | MAPK1BRD4ALDH1A1MAPTRAB9A | |
| SCHEMBL3149403 | 0.71 | MAPK1 (0.62) | MAPK1RAB9AMEN1KMT2ANPSR1 | |
| SCHEMBL1295044 | 0.71 | ALDH1A1 (0.64) | ALDH1A1MAPTMEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719141-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |
| CN-1169986-A | 2.9-diamino-and 2-amino-8-carbamoyl-4-hydroxy-aldanoic acid amide derivatives | CIBA GEIGY AG (CH) | 1998-01-14 | — | — | CN | disclosed |
| EP-0702004-A2 | 2,9-diamino- and 2-amino-8-carbamoyl-4-hydroxy-alkanoic acid amid derivatives | CIBA-GEIGY AG (CH) | 1996-03-20 | — | — | EP | disclosed |