Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.43 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | NAMPT | P43490 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
| ▸ | AHR | P35869 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11966963 | 0.83 | MAPK1 (0.58) | MAPK1NOTUMHSD17B3BRD4CREBBP | |
| SCHEMBL27993916 | 0.77 | MAPK1 (0.48) | MAPK1NOTUMHSD17B3BRD4CREBBP | |
| SCHEMBL12808085 | 0.77 | NOTUM (0.61) | NOTUMHSD17B3ALOX15HSD17B10NAMPT | |
| SCHEMBL28413210 | 0.76 | MAPK1 (0.47) | MAPK1NOTUMHSD17B3BRD4CREBBP | |
| SCHEMBL8561673 | 0.73 | MAPK1 (0.51) | MAPK1BRD4ALOX15NAMPTMAPT | |
| SCHEMBL19673900 | 0.72 | ALOX15 (0.41) | MAPK1NOTUMHSD17B3BRD4CREBBP | |
| SCHEMBL11923135 | 0.72 | BRD4 (0.48) | MAPK1HSD17B3BRD4CREBBPALOX15 | |
| SCHEMBL19657579 | 0.70 | MAPK1 (0.54) | MAPK1NOTUMHSD17B3BRD4CREBBP | |
| SCHEMBL379244 | 0.70 | MAPK1 (0.66) | MAPK1NOTUMHSD17B3BRD4CREBBP | |
| SCHEMBL8244060 | 0.69 | NOTUM (0.68) | MAPK1NOTUMHPGDALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012162365-A1 | SUBSTITUTED SULFONAMIDES USEFUL AS ANTIAPOPTOTIC BCL INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-11-29 | — | — | WO | disclosed |