Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | APAF1 | O14727 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | GABRP | O00591 | 1/20 | 0.44 |
| ▸ | GABRD | O14764 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9125220 | 0.83 | PLCG2 (0.51) | RXFP1NPSR1RAB9ALMNANPC1 | |
| SCHEMBL1304639 | 0.78 | RAB9A (0.68) | RXFP1NPSR1RAB9ALMNANPC1 | |
| SCHEMBL1303958 | 0.74 | RAB9A (0.56) | RXFP1NPSR1RAB9ALMNANPC1 | |
| SCHEMBL8559753 | 0.74 | GAA (0.53) | NPSR1RAB9ALMNANPC1MEN1 | |
| SCHEMBL1304125 | 0.73 | KDM4E (0.56) | RXFP1NPSR1RAB9ANPC1MEN1 | |
| SCHEMBL1302684 | 0.72 | PLTP (0.66) | RXFP1NPSR1RAB9ALMNANPC1 | |
| SCHEMBL1304632 | 0.72 | CETP (0.66) | MEN1KMT2APOLBUSP2MAPT | |
| SCHEMBL1303816 | 0.72 | ADORA1 (0.66) | RXFP1RAB9ALMNANPC1MEN1 | |
| SCHEMBL1304427 | 0.72 | ADORA1 (0.65) | RXFP1RAB9ANPC1MEN1KMT2A | |
| SCHEMBL1304151 | 0.72 | PLTP (0.62) | RAB9ANPC1MEN1KMT2AUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0518731-B1 | 2-(Indol-2-yl-carbonylamino)-thiazole derivatives, their preparation and pharmaceutical compositions containing them | SANOFI SA (FR) | 1998-08-26 | — | — | EP | disclosed |
| EP-0518731-A1 | Heterocyclic derivatives of substituted 2-acylamino 5-thiazole, their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1992-12-16 | — | — | EP | disclosed |