Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 9/20 | 0.63 |
| ▸ | RXFP1 | Q9HBX9 | 6/20 | 0.63 |
| ▸ | LMNA | P02545 | 5/20 | 0.63 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.57 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | CCR6 | P51684 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31133520 | 0.76 | KDM4E (0.72) | LMNAALDH1A1MAPTMEN1HTT | |
| SCHEMBL5810312 | 0.76 | KDM4E (0.72) | LMNAALDH1A1MAPTMEN1HTT | |
| SCHEMBL2918797 | 0.76 | KDM4E (0.67) | TP53LMNAALDH1A1MAPTMEN1 | |
| SCHEMBL13725701 | 0.76 | KDM4E (0.64) | TP53LMNAALDH1A1MAPTMEN1 | |
| SCHEMBL31531878 | 0.75 | KDM4E (0.79) | TP53LMNAALDH1A1MAPTMEN1 | |
| SCHEMBL10678483 | 0.75 | KDM4E (0.79) | TP53LMNAALDH1A1MAPTMEN1 | |
| SCHEMBL7116623 | 0.74 | LMNA (0.49) | TP53RXFP1LMNAALDH1A1MAPT | |
| SCHEMBL13576788 | 0.74 | KDM4E (0.55) | LMNAALDH1A1MAPTMEN1HTT | |
| SCHEMBL3330317 | 0.74 | ALDH1A1 (0.60) | LMNAALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL8562988 | 0.74 | KDM4E (0.72) | ALDH1A1MAPTMEN1HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5814646-A | TREATING THE PROGRESSION OF ALZHEIMER'S DISEASE, BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 1998-09-29 | — | — | US | disclosed |
| US-5624937-A | TREATMENT OF ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY (US) | 1997-04-29 | — | — | US | disclosed |