Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.56 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 2/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | IDH1 | O75874 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8562039 | 1.00 | MTNR1A (0.56) | MTNR1AMTNR1BEPHX2GAAMAPT | |
| SCHEMBL8562033 | 1.00 | MTNR1A (0.56) | MTNR1AMTNR1BEPHX2GAAMAPT | |
| SCHEMBL28038780 | 0.84 | GAA (0.54) | MTNR1AMTNR1BEPHX2GAAMAPT | |
| SCHEMBL29463686 | 0.84 | GAA (0.54) | MTNR1AMTNR1BEPHX2GAAMAPT | |
| SCHEMBL30288898 | 0.84 | GAA (0.54) | MTNR1AMTNR1BEPHX2GAAMAPT | |
| SCHEMBL924219 | 0.84 | GAA (0.54) | MTNR1AMTNR1BEPHX2GAAMAPT | |
| SCHEMBL8562595 | 0.84 | GAA (0.54) | MTNR1AMTNR1BEPHX2GAAMAPT | |
| SCHEMBL5400206 | 0.83 | MTNR1A (0.43) | MTNR1AMTNR1BEPHX2GAAMAPT | |
| SCHEMBL31181154 | 0.83 | MTNR1A (0.49) | MTNR1AMTNR1BEPHX2GAAMAPT | |
| SCHEMBL28114454 | 0.83 | GAA (0.53) | MTNR1AMTNR1BEPHX2GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719141-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |
| EP-0702004-A2 | 2,9-diamino- and 2-amino-8-carbamoyl-4-hydroxy-alkanoic acid amid derivatives | CIBA-GEIGY AG (CH) | 1996-03-20 | — | — | EP | disclosed |