⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8674568 | 0.76 | LMNA (0.58) | — | |
| SCHEMBL12799153 | 0.74 | — | — | |
| SCHEMBL6660333 | 0.74 | — | — | |
| SCHEMBL1438923 | 0.73 | — | — | |
| SCHEMBL8889691 | 0.69 | — | — | |
| SCHEMBL10397541 | 0.69 | DNM1 (0.33) | — | |
| SCHEMBL1155737 | 0.67 | — | — | |
| SCHEMBL8319545 | 0.67 | — | — | |
| SCHEMBL13543019 | 0.67 | — | — | |
| SCHEMBL15053557 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0552060-B1 | Imidazole derivatives having anti-HIV activity | SHIONOGI & CO (JP) | 1998-11-18 | — | — | EP | disclosed |
| EP-0700911-A1 | Imidazole derivatives having anti-HIV activity | SHIONOGI & CO., LTD. (JP) | 1996-03-13 | — | — | EP | disclosed |
| US-5472965-A | Useful for treatment of retrovirus infections; less toxic | SHIONOGI & CO., LTD. (JP) | 1995-12-05 | — | — | US | disclosed |
| US-5326780-A | Acquired immunodeficiency syndrome | SHIONOGI & CO., LTD. (JP) | 1994-07-05 | — | — | US | disclosed |
| EP-0552060-A1 | Imidazole derivatives having anti-HIV activity | SHIONOGI & CO., LTD. (JP) | 1993-07-21 | — | — | EP | disclosed |