Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.55 |
| ▸ | CMA1 | P23946 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8562278 | 1.00 | SIGMAR1 (0.55) | SIGMAR1CMA1KDM4EALDH1A1MAPT | |
| SCHEMBL8562132 | 0.83 | GAA (0.56) | SIGMAR1CMA1ALDH1A1LMNAGAA | |
| SCHEMBL8562128 | 0.83 | GAA (0.56) | SIGMAR1CMA1ALDH1A1LMNAGAA | |
| SCHEMBL369615 | 0.83 | ALDH1A1 (0.44) | SIGMAR1CMA1KDM4EALDH1A1MAPT | |
| SCHEMBL16885927 | 0.82 | MEN1 (0.57) | KDM4EALDH1A1HTTKMT2AACHE | |
| SCHEMBL6828052 | 0.82 | SIGMAR1 (0.56) | SIGMAR1CMA1PKMKMT2A | |
| SCHEMBL28961034 | 0.81 | KMT2A (0.53) | SIGMAR1CMA1KDM4EALDH1A1MAPT | |
| SCHEMBL8567054 | 0.80 | ALDH1A1 (0.55) | SIGMAR1KDM4EALDH1A1KMT2AGAA | |
| SCHEMBL8567056 | 0.80 | ALDH1A1 (0.55) | SIGMAR1KDM4EALDH1A1KMT2AGAA | |
| SCHEMBL12494883 | 0.79 | KMT2A (0.53) | SIGMAR1CMA1KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5804577-A | ANTIBIOTICS | HOFFMANN-LA ROCHE INC. (US) | 1998-09-08 | — | — | US | disclosed |
| CN-1150950-A | Cephalosporin derivatives | HOFFMANN LA ROCHE (CH) | 1997-06-04 | — | — | CN | disclosed |
| EP-0761673-A1 | Cephalosporin derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1997-03-12 | — | — | EP | disclosed |