Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.39 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8501924 | 0.80 | PIK3CA (0.43) | CYP2A6KDM4EPDGFRBPDGFRAALDH1A1 | |
| SCHEMBL8502771 | 0.77 | PIK3CA (0.43) | CYP2A6KDM4EPDGFRBPDGFRAALDH1A1 | |
| SCHEMBL8499783 | 0.76 | ALDH1A1 (0.39) | CYP2A6KDM4EPDGFRBPDGFRAALDH1A1 | |
| SCHEMBL8503319 | 0.74 | KDM4E (0.71) | CYP2A6KDM4EPDGFRBPDGFRAALDH1A1 | |
| SCHEMBL8500059 | 0.74 | NPC1 (0.40) | KDM4EPDGFRBPDGFRAALDH1A1MAPT | |
| SCHEMBL8566324 | 0.73 | BCHE (0.48) | CYP2A6KDM4EPDGFRBPDGFRAALDH1A1 | |
| SCHEMBL8887646 | 0.72 | NPC1 (0.56) | CYP2A6KDM4EPDGFRBPDGFRAALDH1A1 | |
| SCHEMBL23143410 | 0.72 | MAPK1 (0.54) | PDGFRBPDGFRAADORA3SMN1; SMN2NPC1 | |
| SCHEMBL21591641 | 0.71 | ALDH1A1 (0.45) | CYP2A6KDM4EPDGFRBPDGFRAALDH1A1 | |
| SCHEMBL8500901 | 0.71 | PDGFRB (0.71) | KDM4EPDGFRBPDGFRAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5795889-A | INHIBITING CELL GROWTH WITH ENZYME INHIBITORS FOR SKIN DISORDERS | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1998-08-18 | — | — | US | disclosed |
| US-5646153-A | INHIBITING ABNORMAL CELL PROLIFERATION | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1997-07-08 | — | — | US | disclosed |
| US-5480883-A | Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1996-01-02 | — | — | US | disclosed |