Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.57 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.54 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.54 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.51 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.51 |
| ▸ | CACNA1I | Q9P0X4 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | BRD4 | O60885 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | BRS3 | P32247 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8562438 | 1.00 | TDP1 (0.57) | TDP1MTNR1AMTNR1BCACNA1GCACNA1H | |
| SCHEMBL8562434 | 1.00 | TDP1 (0.57) | TDP1MTNR1AMTNR1BCACNA1GCACNA1H | |
| SCHEMBL429807 | 0.90 | MTNR1A (0.58) | TDP1MTNR1AMTNR1BHPGDKMT2A | |
| SCHEMBL431599 | 0.85 | MTNR1A (0.60) | MTNR1AMTNR1BCACNA1GCACNA1HCACNA1I | |
| SCHEMBL8566298 | 0.83 | MTNR1A (0.64) | MTNR1AMTNR1BCACNA1GCACNA1HCACNA1I | |
| SCHEMBL8566307 | 0.83 | MTNR1A (0.64) | MTNR1AMTNR1BCACNA1GCACNA1HCACNA1I | |
| SCHEMBL8566302 | 0.83 | MTNR1A (0.64) | MTNR1AMTNR1BCACNA1GCACNA1HCACNA1I | |
| SCHEMBL10148376 | 0.79 | ALDH1A1 (0.48) | TDP1MTNR1AMTNR1BHPGDKMT2A | |
| SCHEMBL8569399 | 0.77 | NPC1 (0.56) | HPGDL3MBTL1NPC1RAB9AALDH1A1 | |
| SCHEMBL8569404 | 0.77 | NPC1 (0.56) | HPGDL3MBTL1NPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719141-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |
| EP-0702004-A2 | 2,9-diamino- and 2-amino-8-carbamoyl-4-hydroxy-alkanoic acid amid derivatives | CIBA-GEIGY AG (CH) | 1996-03-20 | — | — | EP | disclosed |