Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 7/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | HRH2 | P25021 | 2/20 | 0.39 |
| ▸ | HRH1 | P35367 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR1E | P28566 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 3/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4682332 | 0.82 | ESR1 (0.50) | TMEM97SIGMAR1SLC6A2HRH2HRH1 | |
| SCHEMBL7472118 | 0.81 | ESR1 (0.41) | TMEM97SIGMAR1SLC6A2HRH2HRH1 | |
| SCHEMBL8562345 | 0.80 | ESR1 (0.39) | TMEM97SIGMAR1SLC6A2HRH2HRH1 | |
| SCHEMBL7472374 | 0.80 | TMEM97 (0.43) | TMEM97SIGMAR1SLC6A2HRH2HRH1 | |
| SCHEMBL8897664 | 0.74 | KMT2A (0.37) | MTNR1BESR1ESR2KDM4EALDH1A1 | |
| SCHEMBL8559513 | 0.73 | MTNR1B (0.36) | TMEM97SIGMAR1SLC6A2HRH2HRH1 | |
| SCHEMBL4680153 | 0.71 | ESR1 (0.55) | ESR1ESR2HRH3 | |
| SCHEMBL7560796 | 0.71 | ESR1 (0.42) | TMEM97SIGMAR1SLC6A2HRH2HRH1 | |
| SCHEMBL7474127 | 0.70 | TMEM97 (0.43) | TMEM97SIGMAR1SLC6A2HRH2HRH1 | |
| SCHEMBL8561816 | 0.69 | ESR1 (0.36) | TMEM97SIGMAR1SLC6A2HRH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612741-B1 | Cyclic derivatives, medicaments containing them and process for their preparation | THOMAE GMBH DR K (DE) | 1998-06-10 | — | — | EP | disclosed |
| US-5612335-A | ANTICOAGULANTS; COMBATING/PREVENTING DISEASES WHERE CELL AGGREGATES OCCUR OR CELL-MATRIX INTERACTIONS PLAY A PART | KARL THOMAE GMBH (DE) | 1997-03-18 | — | — | US | disclosed |
| US-5519036-A | IMIDAZOLIDINONES, ANTICOAGULANTS, CELL AGGREGATION PREVENTION | KARL THOMAE GMBH (DE) | 1996-05-21 | — | — | US | disclosed |
| EP-0612741-A1 | Cyclic derivatives, medicaments containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1994-08-31 | — | — | EP | disclosed |