Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 6/20 | 0.69 |
| ▸ | HTR1D | P28221 | 1/20 | 0.69 |
| ▸ | HTR3E | A5X5Y0 | 10/20 | 0.66 |
| ▸ | HTR3B | O95264 | 10/20 | 0.66 |
| ▸ | HTR3A | P46098 | 10/20 | 0.66 |
| ▸ | HTR3D | Q70Z44 | 10/20 | 0.66 |
| ▸ | HTR3C | Q8WXA8 | 10/20 | 0.66 |
| ▸ | HTR1A | P08908 | 6/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2532527 | 0.90 | HTR3E (0.66) | HTR2CHTR1DHTR3EHTR3BHTR3A | |
| SCHEMBL8563726 | 0.85 | HTR3E (0.66) | HTR2CHTR1DHTR3EHTR3BHTR3A | |
| SCHEMBL8564626 | 0.85 | HTR3E (0.75) | HTR2CHTR1DHTR3EHTR3BHTR3A | |
| SCHEMBL8562727 | 0.85 | HTR3E (0.75) | HTR2CHTR1DHTR3EHTR3BHTR3A | |
| SCHEMBL8565092 | 0.84 | HTR3E (0.75) | HTR2CHTR1DHTR3EHTR3BHTR3A | |
| SCHEMBL17221919 | 0.81 | HTR3E (0.69) | HTR2CHTR1DHTR3EHTR3BHTR3A | |
| SCHEMBL8569161 | 0.80 | HTR3E (0.66) | HTR2CHTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL8563992 | 0.80 | HTR3E (0.72) | HTR2CHTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL8566281 | 0.80 | HTR3E (1.00) | HTR2CHTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL8564852 | 0.79 | HTR2C (0.63) | HTR2CHTR1DHTR3EHTR3BHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0623620-B1 | 5-HT3 Pyrrolopyrazine derivatives | ADIR (FR) | 1998-09-09 | — | — | EP | disclosed |
| US-5599812-A | ANTISEROTONINE AGENTS | ADIR ET COMPAGNIE (FR) | 1997-02-04 | — | — | US | disclosed |
| EP-0623620-A1 | 5-HT3 Pyrrolopyrazine derivatives | ADIR ET COMPAGNIE (FR) | 1994-11-09 | — | — | EP | disclosed |