Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.55 |
| ▸ | FAAH | O00519 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9735417 | 0.98 | KDM4E (0.57) | HRH2SMN1; SMN2KDM4EALDH1A1HRH3 | |
| SCHEMBL9734996 | 0.86 | SIGMAR1 (0.51) | KDM4EALDH1A1FAAHTDP1 | |
| SCHEMBL13293747 | 0.85 | HRH3 (0.59) | HRH2SMN1; SMN2KDM4EALDH1A1HRH3 | |
| SCHEMBL10682807 | 0.85 | KDM4E (0.63) | HRH2SMN1; SMN2KDM4EALDH1A1HRH3 | |
| SCHEMBL5167259 | 0.85 | HRH2 (0.59) | HRH2SMN1; SMN2KDM4EALDH1A1HRH3 | |
| SCHEMBL13544385 | 0.85 | HRH3 (0.74) | SMN1; SMN2KDM4EALDH1A1HRH3FAAH | |
| SCHEMBL10934478 | 0.85 | HRH2 (0.59) | HRH2HRH3 | |
| SCHEMBL13293932 | 0.84 | HRH2 (0.58) | HRH2HRH3FAAH | |
| SCHEMBL10689006 | 0.84 | HRH2 (0.61) | HRH2HRH3 | |
| SCHEMBL5288663 | 0.84 | HRH2 (0.61) | HRH2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0159012-B1 | SULFONAMIDINES, A PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | FERRER INTERNACIONAL, S.A. (ES) | 1989-02-01 | — | — | EP | claimed |
| US-4571398-A | Cytosine derivatives having histamine H2 -antagonist activity | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1986-02-18 | — | — | US | claimed |
| EP-0159012-A2 | Sulfonamidines, a process for preparing them and pharmaceutical compositions containing them | FERRER INTERNACIONAL, S.A. (ES) | 1985-10-23 | — | — | EP | claimed |
| US-4526973-A | Amino substituted, diketone group-containing cyclobutene derivative | BRISTOL-MYERS COMPANY (US) | 1985-07-02 | — | — | US | claimed |
| US-4522943-A | ANTISECRETORY ANTIULCER AGENT | BRISTOL-MYERS COMPANY (US) | 1985-06-11 | — | — | US | claimed |
| EP-0140466-A2 | Pyrimidinone derivatives, process for their preparation, and their pharmaceutical use | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-05-08 | — | — | EP | claimed |
| EP-0123920-A1 | N-cyano-formamidine compounds, process for preparing them and pharmaceutical compositions containing them | FERRER INTERNACIONAL, S.A. (ES) | 1984-11-07 | — | — | EP | claimed |
| US-5821250-A | Dihydrobenzofuran and related compounds useful as anti-inflammatory agents | THE PROCTER & GAMBLE COMPANY (US) | 1998-10-13 | — | — | US | disclosed |
| US-5276030-A | Tranquilizers, antispasmodics, antidepressants | EGIS GYOGYSZERGYAT (HU) | 1994-01-04 | — | — | US | disclosed |
| US-5175163-A | Tranquilizer, antidepresant, antispasmodic, analgesic and antiinflammatory agent | EGIS GYOGYSZERGYAR (HU) | 1992-12-29 | — | — | US | disclosed |
| EP-0180298-B1 | PYRIMIDINE COMPOUNDS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1991-09-25 | — | — | EP | disclosed |
| EP-0434982-A2 | 5-(Amino)-triazolylcarbothioamide derivatives, process for their preparation and medicines containing them, as well as use of the former | EGIS GYOGYSZERGYAR (HU) | 1991-07-03 | — | — | EP | disclosed |
| EP-0159012-B1 | SULFONAMIDINES, A PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | FERRER INTERNACIONAL, S.A. (ES) | 1989-02-01 | — | — | EP | disclosed |
| EP-0172968-A1 | Aminothiadiazine derivatives as histamine H2-antagonists | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1986-03-05 | — | — | EP | disclosed |
| US-4571398-A | Cytosine derivatives having histamine H2 -antagonist activity | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1986-02-18 | — | — | US | disclosed |
| EP-0159012-A2 | Sulfonamidines, a process for preparing them and pharmaceutical compositions containing them | FERRER INTERNACIONAL, S.A. (ES) | 1985-10-23 | — | — | EP | disclosed |
| EP-0143630-A2 | Chemical compounds | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-06-05 | — | — | EP | disclosed |
| EP-0140466-A2 | Pyrimidinone derivatives, process for their preparation, and their pharmaceutical use | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-05-08 | — | — | EP | disclosed |
| EP-0134096-A2 | Aminopyrimidinone derivatives as histamine H2-antagonists | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-03-13 | — | — | EP | disclosed |
| EP-0123920-A1 | N-cyano-formamidine compounds, process for preparing them and pharmaceutical compositions containing them | FERRER INTERNACIONAL, S.A. (ES) | 1984-11-07 | — | — | EP | disclosed |