Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO1 | P15559 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | LTA4H | P09960 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL826487 | 0.85 | — | — | |
| SCHEMBL18067916 | 0.83 | NQO1 (0.39) | NQO1ALDH1A1TSHRTDP1HSD17B10 | |
| SCHEMBL15624566 | 0.83 | — | — | |
| SCHEMBL15352897 | 0.79 | DAO (0.38) | NQO1ALDH1A1TSHRTDP1HSD17B10 | |
| SCHEMBL10565399 | 0.79 | NQO1 (0.36) | NQO1ALDH1A1TSHRTDP1HSD17B10 | |
| SCHEMBL16901839 | 0.78 | ALDH1A1 (0.46) | NQO1ALDH1A1CYP3A4 | |
| SCHEMBL29954952 | 0.78 | TSHR (0.42) | NQO1ALDH1A1TSHRLTA4H | |
| SCHEMBL7895818 | 0.76 | ALDH1A1 (0.54) | ALDH1A1TDP1KDM4EHPGDMAPT | |
| SCHEMBL3053104 | 0.75 | HPGD (0.39) | ALDH1A1TSHRTDP1MAPK1NPC1 | |
| SCHEMBL5645214 | 0.73 | MAPT (0.44) | ALDH1A1HSD17B10KDM4EMAPK1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756730-A | Process for preparing analgesic compounds | SANKYO COMPANY, LIMITED (JP) | 1998-05-26 | — | — | US | disclosed |
| CN-1036004-C | Process for preparing analgesic carboxylic acid amide derivatives | SANKYO CO (JP) | 1997-10-01 | — | — | CN | disclosed |
| US-5656758-A | AMIDATION OF AN AMINE-CONTAINING THIOMORPHOLINE OR PIPERAZINE COMPOUND | SANKYO COMPANY, LIMITED (JP) | 1997-08-12 | — | — | US | disclosed |
| CN-1034731-C | Process for preparing analgesic carboxylic acid amide derivatives | SANKYO CO (JP) | 1997-04-30 | — | — | CN | disclosed |
| US-5512567-A | KAPPA-RECEPTOR AGONISTS | SANKYO COMPANY, LIMITED (JP) | 1996-04-30 | — | — | US | disclosed |
| CN-1030450-C | Preparation of analgesic carboxylic acid amides derivative | SANKYO CO (JP) | 1995-12-06 | — | — | CN | disclosed |
| CN-1079741-A | The preparation method of analgesic carboxylic acid amide derivatives | SANKYO CO (JP) | 1993-12-22 | — | — | CN | disclosed |
| CN-1079740-A | The preparation method of analgesic carboxylic acid amide derivatives | SANKYO CO (JP) | 1993-12-22 | — | — | CN | disclosed |
| US-5270327-A | Piperidine derivatives | SANKYO COMPANY, LIMITED (JP) | 1993-12-14 | — | — | US | disclosed |
| CN-1078461-A | The preparation method of analgesic carboxylic acid amide derivatives | SANKYO CO (JP) | 1993-11-17 | — | — | CN | disclosed |
| CN-1022185-C | Process for preparing analgesic carboxylic acid amide derivatives | SANKYO CO (JP) | 1993-09-22 | — | — | CN | disclosed |
| EP-0356247-B1 | ANALGESIC CARBOXYLIC ACID AMIDE DERIVATIVES | Sankyo Company Limited (JP) | 1993-03-17 | — | — | EP | disclosed |
| US-5021413-A | Analgesic thiomorpholins their preparation, and pharmaceutical compositions containing them | SANKYO COMPANY LIMITED (JP) | 1991-06-04 | — | — | US | disclosed |
| CN-1040791-A | ANALGESIC CARBOXYLIC ACID AMIDE DERIVATIVES | SANKYO CO (JP) | 1990-03-28 | — | — | CN | disclosed |
| EP-0356247-A1 | Analgesic carboxylic acid amide derivatives | Sankyo Company Limited (JP) | 1990-02-28 | — | — | EP | disclosed |