Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4371738 | 0.90 | CYP1A2 (0.44) | ALDH1A1HPGDKDM4EHTTRECQL | |
| SCHEMBL11325666 | 0.88 | ALDH1A1 (0.45) | ALDH1A1HPGDKDM4EHTTRECQL | |
| SCHEMBL27836922 | 0.87 | ALDH1A1 (0.40) | ALDH1A1HPGDKDM4EHTTRECQL | |
| SCHEMBL2472768 | 0.86 | ALDH1A1 (0.41) | ALDH1A1HPGDKDM4EHTTRECQL | |
| SCHEMBL7300673 | 0.82 | CYP1A2 (0.42) | ALDH1A1HPGDKDM4EHTTRECQL | |
| SCHEMBL20295385 | 0.81 | ALDH1A1 (0.47) | ALDH1A1HPGDKDM4EHTTRECQL | |
| SCHEMBL5809049 | 0.81 | ALDH1A1 (0.47) | ALDH1A1HPGDKDM4EHTTRECQL | |
| SCHEMBL27352613 | 0.81 | GLA (0.34) | ALDH1A1KDM4EPOLBKMT2AMAPK1 | |
| SCHEMBL1275935 | 0.80 | ALDH1A1 (0.46) | ALDH1A1HPGDKDM4EHTTRECQL | |
| SCHEMBL11049418 | 0.80 | GLA (0.33) | ALDH1A1CYP1A2CYP2C9CYP2C19LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020043025-A1 | HYDRATE OF 4-(1-HYDROXY-1-METHYLETHYL)-2-PROPYLIMIDAZOLE-5-CARBOXYLIC ACID ETHYL ESTER | 黄冈鲁班药业股份有限公司 | 2020-03-05 | — | — | WO | disclosed |
| EP-0603001-B1 | Biphenyl derivatives, their preparation and their use for the treatment of hypertension and cardiac disease | SANKYO CO (JP) | 1998-08-26 | — | — | EP | disclosed |
| US-5459148-A | Cardiovascular disorders | SANKYO COMPANY, LIMITED (JP) | 1995-10-17 | — | — | US | disclosed |
| EP-0603001-A1 | Biphenyl derivatives, their preparation and their use for the treatment of hypertension and cardiac disease | SANKYO COMPANY LIMITED (JP) | 1994-06-22 | — | — | EP | disclosed |