Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27859622 | 0.79 | HRH3 (0.35) | TSHREPHX2HRH3KMT2AALDH1A1 | |
| SCHEMBL28014498 | 0.78 | CYP4F2 (0.42) | TSHREPHX2ALDH1A1MAPTHTT | |
| SCHEMBL10916991 | 0.76 | CYP4F2 (0.44) | TSHREPHX2ALDH1A1MAPTHTT | |
| SCHEMBL10665467 | 0.73 | FFAR1 (0.42) | LMNAALDH1A1MAPK1SMN1; SMN2 | |
| Cyclohexane SCHEMBL1289332 | 0.72 | TSHR (0.74) | TSHREPHX2KMT2ALMNAALDH1A1 | |
| SCHEMBL16649242 | 0.72 | ALDH1A1 (0.52) | TSHRKMT2ALMNAALDH1A1MAPT | |
| SCHEMBL3608741 | 0.71 | FFAR1 (0.41) | LMNAALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL22922181 | 0.71 | CYP4F2 (0.59) | TSHREPHX2HRH3KMT2ALMNA | |
| SCHEMBL493858 | 0.71 | TSHR (0.43) | TSHREPHX2KMT2ALMNAALDH1A1 | |
| SCHEMBL5195370 | 0.70 | FFAR1 (0.43) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5707989-A | ANTITUMOR AGENTS, INHIBITING SIGNAL TRANSDUCTION MEDIATED BY TYROSINE KINASES | DR. KARL THOMAE GMBH (DE) | 1998-01-13 | — | — | US | claimed |
| US-5827849-A | HAVING INHIBITORY EFFECT ON INFLAMMATION AND BONE DEGRADATION, ANTITHROMBOTIC, ANTIAGGREGATORY AND TUMOR- OR METASTASIS-INHIBITING EFFECT | KARL THOMAE GMBH (DE) | 1998-10-27 | — | — | US | disclosed |
| US-5707989-A | ANTITUMOR AGENTS, INHIBITING SIGNAL TRANSDUCTION MEDIATED BY TYROSINE KINASES | DR. KARL THOMAE GMBH (DE) | 1998-01-13 | — | — | US | disclosed |