Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 4/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4405605 | 0.82 | HDAC6 (0.68) | HDAC6RAB9AL3MBTL1NPC1ALDH1A1 | |
| SCHEMBL4161458 | 0.78 | RAB9A (0.59) | HDAC6RAB9AL3MBTL1NPC1ALDH1A1 | |
| SCHEMBL27164148 | 0.75 | TAAR1 (0.43) | RAB9ANPC1KDM4EALDH1A1LMNA | |
| SCHEMBL4409125 | 0.74 | RAB9A (0.59) | HDAC6RAB9AL3MBTL1NPC1ALDH1A1 | |
| SCHEMBL8021985 | 0.74 | HDAC6 (0.52) | HDAC6RAB9AL3MBTL1NPC1KDM4E | |
| SCHEMBL4405809 | 0.74 | RAB9A (0.62) | HDAC6RAB9AL3MBTL1GRM2NPC1 | |
| SCHEMBL7829183 | 0.73 | HDAC6 (0.48) | HDAC6RAB9AL3MBTL1NPC1ALDH1A1 | |
| SCHEMBL7830747 | 0.72 | HDAC6 (0.43) | HDAC6RAB9AL3MBTL1NPC1ALDH1A1 | |
| SCHEMBL4411921 | 0.72 | RAB9A (0.56) | HDAC6RAB9AL3MBTL1NPC1CNR2 | |
| SCHEMBL31272767 | 0.71 | HDAC6 (0.58) | HDAC6RAB9AL3MBTL1NPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880522-A1 | 5H,10H-IMIDAZO 1,2-a]INDENO 1,2-e]PYRAZINE-4-ONE DERIVATIVES, PREPARATION THEREOF, INTERMEDIATES THEREOF AND DRUGS CONTAINING SAME | Aventis Pharma S.A. (FR) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997025328-A1 | 5H,10H-IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZINE-4-ONE DERIVATIVES, PREPARATION THEREOF, INTERMEDIATES THEREOF AND DRUGS CONTAINING SAME | RHONE-POULENC RORER S.A. (FR) | 1997-07-17 | — | — | WO | disclosed |