SCHEMBL8021985

SCHEMBL8021985

O=C(O)C=Cc1ccccc1Cc1nnn(Cc2ccccc2)n1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 2/20 0.52
PTGER3 P43115 6/20 0.50
PTGDR Q13258 5/20 0.50
PTGER2 P43116 5/20 0.50
TBXA2R P21731 4/20 0.50
PTGFR P43088 3/20 0.50
PTGER4 P35408 3/20 0.50
PTGIR P43119 2/20 0.50
PTGER1 P34995 1/20 0.50
GAA P10253 1/20 0.49
PKM P14618 1/20 0.46
TBXAS1 P24557 1/20 0.46
MEN1 O00255 1/20 0.45
KMT2A Q03164 1/20 0.45
ATM Q13315 1/20 0.45
SMN1; SMN2 Q16637 2/20 0.44
RAB9A P51151 2/20 0.42
NPC1 O15118 1/20 0.42
CNR2 P34972 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL157606 0.76 PTGER3 (0.73) HDAC6PTGER3PTGDRPTGER2TBXA2R
SCHEMBL4405605 0.74 HDAC6 (0.68) HDAC6SMN1; SMN2RAB9ANPC1CNR2
SCHEMBL8563039 0.74 HDAC6 (0.54) HDAC6ATMSMN1; SMN2RAB9ANPC1
SCHEMBL18076297 0.69 PTGER3 (0.58) PTGER3PTGDRPTGER2TBXA2RPTGFR
SCHEMBL1716822 0.69 PTGER3 (0.58) PTGER3PTGDRPTGER2TBXA2RPTGFR
SCHEMBL20534883 0.68 HDAC6 (1.00) HDAC6CNR2
SCHEMBL7113310 0.68 PTGER3 (0.61) HDAC6PTGER3PTGDRPTGER2TBXA2R
SCHEMBL7829183 0.68 HDAC6 (0.48) HDAC6GAAKMT2ASMN1; SMN2RAB9A
SCHEMBL2722894 0.68 NFKB1 (0.66) HDAC6PTGER3PTGDRPTGER2TBXA2R
SCHEMBL4409125 0.67 RAB9A (0.59) HDAC6MEN1KMT2AATMSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6100264-A 5H, 10H-imidazo [1,2-A] indeno [1,2-E] pyrazin-4-one derivatives, their preparation, their intermediates and medicaments containing them RHONE-POULENC RORER, S.A. (FR) 2000-08-08 US disclosed
US-5990108-A USEFUL AS ANTAGONISTS OF THE ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID (AMPA) RECEPTOR, ALSO KNOWN AS THE QUISQUALATE RECEPTOR, AND AS ANTAGONISTS OF THE N-METHYL-D-ASPARTATE (NMDA) RECEPTOR RHONE POULENC RORER S.A. (FR) 1999-11-23 US disclosed