Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 5/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.35 |
| ▸ | TACR2 | P21452 | 1/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.34 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | FNTA | P49354 | 1/20 | 0.34 |
| ▸ | FNTB | P49356 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8559596 | 0.86 | TACR2 (0.46) | CCR5TACR2MEN1KMT2A | |
| SCHEMBL14415552 | 0.79 | CCR5 (0.46) | CCR5PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8970579 | 0.76 | SLC6A2 (0.41) | SLC6A3 | |
| SCHEMBL5510972 | 0.75 | CCR5 (0.44) | CCR5OPRK1PDE4APDE4BPDE4C | |
| SCHEMBL3467820 | 0.75 | CCR5 (0.42) | CCR5PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3467818 | 0.75 | CCR5 (0.42) | CCR5PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8970672 | 0.74 | TACR1 (0.47) | CCR5TACR2 | |
| SCHEMBL3466112 | 0.74 | CCR5 (0.48) | CCR5PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3466111 | 0.74 | CCR5 (0.48) | CCR5PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4680501 | 0.74 | CCR5 (0.45) | CCR5PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5726313-A | Substituted arylaliphatic compounds, method of preparing them and pharmaceutical compositions in which they are present | SANOFI (FR) | 1998-03-10 | — | — | US | disclosed |
| EP-0700386-A1 | NEUROKININ RECEPTOR ANTAGONISTS | SANOFI (FR) | 1996-03-13 | — | — | EP | disclosed |
| WO-1995026338-A1 | NEUROKININ RECEPTOR ANTAGONISTS | SANOFI (FR) | 1995-10-05 | — | — | WO | disclosed |