SCHEMBL8563159

SCHEMBL8563159

FC(F)(F)c1cccc(Oc2nc(I)cc(OCc3ccccc3)n2)c1

nearest known ligand 0.46

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MRGPRX4 Q96LA9 1/20 0.46
L3MBTL1 Q9Y468 2/20 0.43
NR4A2 P43354 2/20 0.43
ALDH1A1 P00352 1/20 0.43
POLB P06746 1/20 0.43
CYP1A2 P05177 1/20 0.42
CYP2C9 P11712 1/20 0.42
CYP2C19 P33261 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
MAOB P27338 4/20 0.41
ABCG2 Q9UNQ0 1/20 0.41
PPARG P37231 1/20 0.41
PPARA Q07869 1/20 0.41
ADORA2A P29274 1/20 0.41
PLA2G7 Q13093 1/20 0.40
CACNA1B Q00975 1/20 0.40
GAA P10253 1/20 0.40
MAPT P10636 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8669456 0.91 L3MBTL1 (0.46) MRGPRX4L3MBTL1NR4A2ALDH1A1POLB
SCHEMBL8565671 0.88 MRGPRX4 (0.46) MRGPRX4L3MBTL1NR4A2ALDH1A1POLB
SCHEMBL8565553 0.87 MRGPRX4 (0.45) MRGPRX4L3MBTL1NR4A2ALDH1A1POLB
SCHEMBL8557132 0.85 MRGPRX4 (0.46) MRGPRX4L3MBTL1NR4A2ALDH1A1POLB
SCHEMBL8563281 0.84 MRGPRX4 (0.42) MRGPRX4L3MBTL1NR4A2ALDH1A1POLB
SCHEMBL8508415 0.83 MAPT (0.52) MRGPRX4L3MBTL1NR4A2ALDH1A1POLB
SCHEMBL8773242 0.80 MAOB (0.48) MRGPRX4L3MBTL1NR4A2ALDH1A1POLB
SCHEMBL8558636 0.79 MAOB (0.45) L3MBTL1ALDH1A1POLBNPSR1MAOB
SCHEMBL8664724 0.78 ALDH1A1 (0.46) MRGPRX4L3MBTL1NR4A2ALDH1A1POLB
SCHEMBL8669447 0.78 L3MBTL1 (0.45) MRGPRX4L3MBTL1NR4A2ALDH1A1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5726128-A Benzyloxypyrimidine derivative, processes for producing the same and herbicidal composition KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1998-03-10 US disclosed
EP-0707001-A1 Benzyloxypyrimidine derivative, processes for producing the same and herbicidal composition KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1996-04-17 EP disclosed