Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | GALR2 | O43603 | 1/20 | 0.51 |
| ▸ | MITF | O75030 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | XBP1 | P17861 | 1/20 | 0.51 |
| ▸ | CCR6 | P51684 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | KCNMA1 | Q12791 | 3/20 | 0.43 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2129921 | 0.89 | NPSR1 (0.50) | MAPTNPSR1POLBSMN1; SMN2GALR2 | |
| SCHEMBL2128713 | 0.87 | SMN1; SMN2 (0.54) | MAPTNPSR1POLBSMN1; SMN2GALR2 | |
| SCHEMBL27426629 | 0.85 | RECQL (0.48) | MAPTNPSR1POLBSMN1; SMN2GALR2 | |
| SCHEMBL29405447 | 0.83 | NPSR1 (0.50) | MAPTNPSR1POLBSMN1; SMN2GALR2 | |
| SCHEMBL21989034 | 0.83 | SLC9A1 (0.52) | MAPTNPSR1POLBSMN1; SMN2GALR2 | |
| SCHEMBL11095126 | 0.83 | MAPT (0.52) | MAPTNPSR1POLBSMN1; SMN2GALR2 | |
| SCHEMBL8767277 | 0.81 | MAPT (0.51) | MAPTNPSR1POLBSMN1; SMN2GALR2 | |
| SCHEMBL11951437 | 0.81 | ALDH1A1 (0.51) | MAPTNPSR1POLBSMN1; SMN2GALR2 | |
| SCHEMBL13811009 | 0.79 | NPSR1 (0.49) | MAPTNPSR1POLBSMN1; SMN2GALR2 | |
| SCHEMBL8954112 | 0.78 | SMN1; SMN2 (0.58) | MAPTNPSR1POLBSMN1; SMN2GALR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0431943-B1 | Spiro(pyran)piperidine derivatives | MERCK & CO INC (US) | 1998-07-15 | — | — | EP | disclosed |
| US-5633247-A | ANTIARRTHYMIA AGENT | MERCK & CO., INC. (US) | 1997-05-27 | — | — | US | disclosed |
| CN-1110685-A | Nitrogen-containing spiro ring | MERCK & CO INC (US) | 1995-10-25 | — | — | CN | disclosed |
| US-5206240-A | Antiarrhythmia agents | MERCK & CO., INC. (US) | 1993-04-27 | — | — | US | disclosed |
| CN-1053613-A | Nitrogen-containing spiro ring | MERCK & CO INC (US) | 1991-08-07 | — | — | CN | disclosed |
| EP-0431943-A2 | Nitrogen-containing spirocycles | MERCK & CO. INC. (US) | 1991-06-12 | — | — | EP | disclosed |