Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 12/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 2/20 | 0.34 |
| ▸ | RARG | P13631 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.33 |
| ▸ | PPARA | Q07869 | 3/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8309388 | 0.76 | PPARG (0.44) | PPARGFFAR1KDM4EMAPTRXRA | |
| SCHEMBL8565269 | 0.75 | PPARG (0.57) | PPARGFFAR1MAPTRXRACYP3A4 | |
| SCHEMBL8305019 | 0.75 | RECQL (0.42) | PPARGFFAR1KDM4EMAPTCTSK | |
| SCHEMBL8857154 | 0.74 | PPARG (0.43) | PPARGFFAR1KDM4EMAPTCYP2C9 | |
| SCHEMBL27516237 | 0.74 | MAPT (0.51) | PPARGKDM4EMAPTCYP3A4CYP2C9 | |
| SCHEMBL9204965 | 0.74 | PPARG (0.56) | PPARGFFAR1MAPTRXRACYP3A4 | |
| SCHEMBL9204981 | 0.74 | PPARG (0.56) | PPARGFFAR1MAPTRXRACYP3A4 | |
| SCHEMBL8304179 | 0.74 | MCL1 (0.41) | PPARGKDM4EMAPTMCL1 | |
| SCHEMBL7832480 | 0.74 | KDM4E (0.43) | PPARGFFAR1KDM4EMAPTRXRA | |
| SCHEMBL8308949 | 0.73 | PPARG (0.38) | PPARGFFAR1KDM4EMAPTRXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0549366-B1 | Thiazolidine compounds containing a quinone group, their preparation and their therapeutic uses | SANKYO CO (JP) | 1998-04-15 | — | — | EP | disclosed |
| EP-0549365-B1 | Thiazolidine compounds, their preparation and their therapeutic uses | SANKYO CO (JP) | 1995-08-09 | — | — | EP | disclosed |
| US-5338855-A | Treating diabetes or hyperlipemia | SANKYO COMPANY, LIMITED (JP) | 1994-08-16 | — | — | US | disclosed |
| EP-0549366-A1 | Thiazolidine compounds containing a quinone group, their preparation and their therapeutic uses | Sankyo Company Limited (JP) | 1993-06-30 | — | — | EP | disclosed |
| EP-0549365-A1 | Thiazolidine compounds, their preparation and their therapeutic uses | Sankyo Company Limited (JP) | 1993-06-30 | — | — | EP | disclosed |