Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX1 | Q9Y5S8 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | SNCA | P37840 | 2/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | RYR2 | Q92736 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10671438 | 0.88 | NOX1 (0.61) | NOX1LMNAMAPTMAPK1MEN1 | |
| SCHEMBL8558747 | 0.88 | NOX1 (0.61) | NOX1LMNAMAPTMAPK1MEN1 | |
| SCHEMBL4510651 | 0.77 | GAA (0.52) | NOX1MAPTMAPK1MEN1GAA | |
| SCHEMBL8562468 | 0.77 | NOX1 (0.58) | NOX1LMNAMAPTMAPK1MEN1 | |
| Phenothiazine SCHEMBL9074312 | 0.76 | NOX1 (1.00) | NOX1LMNAMAPTMAPK1MEN1 | |
| SCHEMBL29936312 | 0.76 | NOX1 (0.53) | NOX1LMNAMAPTMAPK1MEN1 | |
| SCHEMBL29278502 | 0.76 | NOX1 (0.53) | NOX1LMNAMAPTMAPK1MEN1 | |
| SCHEMBL239600 | 0.76 | NOX1 (1.00) | NOX1LMNAMAPTMAPK1MEN1 | |
| Benzene SCHEMBL29242182 | 0.75 | NOX1 (0.97) | NOX1LMNAMAPTMAPK1MEN1 | |
| SCHEMBL25414339 | 0.74 | PDE3B (0.45) | NOX1LMNAMAPTMAPK1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640592-B1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID CO (US) | 1998-12-30 | — | — | EP | disclosed |
| EP-0640592-A1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID COMPANY (US) | 1995-03-01 | — | — | EP | disclosed |