Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.68 |
| ▸ | LMNA | P02545 | 4/20 | 0.68 |
| ▸ | HTT | P42858 | 3/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 6/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | HSPB1 | P04792 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11109000 | 0.79 | HTT (0.47) | RAB9ALMNAHTTALDH1A1KDM4E | |
| SCHEMBL199906 | 0.78 | HTT (0.58) | RAB9ALMNAHTTALDH1A1KDM4E | |
| SCHEMBL31595897 | 0.78 | HTT (0.58) | RAB9ALMNAHTTALDH1A1KDM4E | |
| SCHEMBL29287094 | 0.78 | NQO2 (0.46) | RAB9ALMNAHTTALDH1A1KDM4E | |
| SCHEMBL22926807 | 0.77 | HSPB1 (0.60) | RAB9ALMNAHTTALDH1A1MAPT | |
| SCHEMBL30465466 | 0.77 | RAB9A (0.44) | RAB9ALMNAHTTALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL27672403 | 0.77 | HTT (0.56) | RAB9ALMNAHTTALDH1A1KDM4E | |
| SCHEMBL28342438 | 0.77 | HTT (0.56) | RAB9ALMNAHTTALDH1A1KDM4E | |
| SCHEMBL11012312 | 0.76 | HTT (0.68) | RAB9ALMNAHTTALDH1A1KDM4E | |
| SCHEMBL10847357 | 0.76 | AR (0.51) | RAB9ALMNAHTTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5814646-A | TREATING THE PROGRESSION OF ALZHEIMER'S DISEASE, BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 1998-09-29 | — | — | US | disclosed |
| US-5624937-A | TREATMENT OF ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY (US) | 1997-04-29 | — | — | US | disclosed |