Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.54 |
| ▸ | RAB9A | P51151 | 5/20 | 0.54 |
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.51 |
| ▸ | KDM1A | O60341 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | HTT | P42858 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | GFER | P55789 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | CTSD | P07339 | 1/20 | 0.46 |
| ▸ | CASP6 | P55212 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28030477 | 0.91 | DDAH1 (0.54) | KMT2ARAB9ANPC1MEN1DDAH1 | |
| SCHEMBL10587516 | 0.86 | DDAH1 (0.53) | KMT2ARAB9ANPC1MEN1DDAH1 | |
| SCHEMBL28813270 | 0.83 | KMT2A (0.48) | KMT2ARAB9ANPC1MEN1DDAH1 | |
| SCHEMBL11588358 | 0.83 | KMT2A (0.51) | KMT2ARAB9ANPC1MEN1DDAH1 | |
| SCHEMBL8363008 | 0.83 | RAB9A (0.58) | KMT2ARAB9ANPC1MEN1DDAH1 | |
| SCHEMBL28366757 | 0.82 | DDAH1 (0.59) | KMT2ARAB9ANPC1MEN1DDAH1 | |
| SCHEMBL8561564 | 0.80 | KMT2A (0.48) | KMT2ARAB9ANPC1MEN1DDAH1 | |
| SCHEMBL27974300 | 0.80 | MAPT (0.60) | KMT2ARAB9ANPC1MEN1DDAH1 | |
| SCHEMBL11343149 | 0.77 | MAPT (0.67) | KMT2ARAB9ANPC1MEN1MAPT | |
| SCHEMBL28822248 | 0.77 | KMT2A (0.55) | KMT2ARAB9ANPC1MEN1DDAH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5814646-A | TREATING THE PROGRESSION OF ALZHEIMER'S DISEASE, BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 1998-09-29 | — | — | US | disclosed |
| US-5624937-A | TREATMENT OF ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY (US) | 1997-04-29 | — | — | US | disclosed |