Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | BUB1 | O43683 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 2/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | IDH1 | O75874 | 1/20 | 0.33 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8563701 | 1.00 | EPHX2 (0.61) | EPHX2MAPK1MTNR1AMTNR1BGAA | |
| SCHEMBL8563699 | 1.00 | EPHX2 (0.61) | EPHX2MAPK1MTNR1AMTNR1BGAA | |
| SCHEMBL28380235 | 0.87 | EPHX2 (0.54) | EPHX2MAPK1MTNR1AMTNR1BGAA | |
| SCHEMBL2031526 | 0.85 | EPHX2 (0.53) | EPHX2MAPK1MTNR1AMTNR1BGAA | |
| SCHEMBL8562535 | 0.85 | EPHX2 (0.53) | EPHX2MAPK1MTNR1AMTNR1BGAA | |
| SCHEMBL8562539 | 0.85 | EPHX2 (0.53) | EPHX2MAPK1MTNR1AMTNR1BGAA | |
| SCHEMBL8567784 | 0.81 | MTNR1A (0.49) | EPHX2MTNR1AMTNR1BMAPTBRD4 | |
| SCHEMBL8564153 | 0.81 | EPHX2 (0.47) | EPHX2MAPK1MTNR1AMTNR1BGAA | |
| SCHEMBL431522 | 0.81 | MTNR1A (0.49) | EPHX2MTNR1AMTNR1BMAPTBRD4 | |
| SCHEMBL8567787 | 0.81 | MTNR1A (0.49) | EPHX2MTNR1AMTNR1BMAPTBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2527339-A1 | Chromanylurea compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor and uses thereof | Abbott Laboratories (US) | 2012-11-28 | — | — | EP | disclosed |
| US-5719141-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |