Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30576465 | 1.00 | MTNR1A (0.49) | MTNR1AMTNR1BBRD4EPHX2KDM4E | |
| SCHEMBL8567787 | 1.00 | MTNR1A (0.49) | MTNR1AMTNR1BBRD4EPHX2KDM4E | |
| SCHEMBL431522 | 1.00 | MTNR1A (0.49) | MTNR1AMTNR1BBRD4EPHX2KDM4E | |
| SCHEMBL8304093 | 0.86 | MTNR1A (0.50) | MTNR1AMTNR1BBRD4EPHX2KMT2A | |
| SCHEMBL13610178 | 0.84 | PPARG (0.45) | MTNR1AMTNR1BEPHX2KDM4ETSHR | |
| SCHEMBL2031526 | 0.84 | EPHX2 (0.53) | MTNR1AMTNR1BBRD4EPHX2KMT2A | |
| SCHEMBL8562539 | 0.84 | EPHX2 (0.53) | MTNR1AMTNR1BBRD4EPHX2KMT2A | |
| SCHEMBL8562535 | 0.84 | EPHX2 (0.53) | MTNR1AMTNR1BBRD4EPHX2KMT2A | |
| SCHEMBL10148374 | 0.83 | ALDH1A1 (0.42) | KDM4ETSHRKMT2AALDH1A1MEN1 | |
| SCHEMBL7499391 | 0.81 | MTNR1A (0.46) | MTNR1AMTNR1BBRD4EPHX2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719141-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |
| EP-0702004-A2 | 2,9-diamino- and 2-amino-8-carbamoyl-4-hydroxy-alkanoic acid amid derivatives | CIBA-GEIGY AG (CH) | 1996-03-20 | — | — | EP | disclosed |