Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 4/20 | 0.38 |
| ▸ | HTR2C | P28335 | 4/20 | 0.38 |
| ▸ | HTR2B | P41595 | 4/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8561415 | 0.85 | HRH3 (0.43) | OPRK1CYP3A4HRH3 | |
| Hydrochloric Acid SCHEMBL8557411 | 0.85 | OPRK1 (0.43) | OPRK1CYP3A4HRH3 | |
| SCHEMBL8562812 | 0.83 | OPRK1 (0.40) | OPRK1CYP3A4THRB | |
| SCHEMBL8559617 | 0.83 | UTS2R (0.44) | OPRK1HCRTR1HCRTR2CYP3A4THRB | |
| SCHEMBL8561543 | 0.82 | OPRK1 (0.40) | OPRK1THRBHRH3 | |
| Hydrochloric Acid SCHEMBL8560547 | 0.82 | OPRK1 (0.40) | OPRK1CYP3A4THRB | |
| Hydrochloric Acid SCHEMBL8565651 | 0.82 | UTS2R (0.43) | OPRK1HCRTR1HCRTR2CYP3A4THRB | |
| SCHEMBL8566739 | 0.81 | OPRK1 (0.39) | OPRK1THRBHRH3 | |
| Hydrochloric Acid SCHEMBL8556863 | 0.81 | OPRK1 (0.39) | OPRK1THRBHRH3 | |
| SCHEMBL27264297 | 0.81 | HTR2A (0.36) | HTR2AHTR2CHTR2BHCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756730-A | Process for preparing analgesic compounds | SANKYO COMPANY, LIMITED (JP) | 1998-05-26 | — | — | US | disclosed |
| US-5656758-A | AMIDATION OF AN AMINE-CONTAINING THIOMORPHOLINE OR PIPERAZINE COMPOUND | SANKYO COMPANY, LIMITED (JP) | 1997-08-12 | — | — | US | disclosed |
| US-5512567-A | KAPPA-RECEPTOR AGONISTS | SANKYO COMPANY, LIMITED (JP) | 1996-04-30 | — | — | US | disclosed |
| US-5270327-A | Piperidine derivatives | SANKYO COMPANY, LIMITED (JP) | 1993-12-14 | — | — | US | disclosed |
| EP-0356247-B1 | ANALGESIC CARBOXYLIC ACID AMIDE DERIVATIVES | Sankyo Company Limited (JP) | 1993-03-17 | — | — | EP | disclosed |
| US-5021413-A | Analgesic thiomorpholins their preparation, and pharmaceutical compositions containing them | SANKYO COMPANY LIMITED (JP) | 1991-06-04 | — | — | US | disclosed |
| EP-0356247-A1 | Analgesic carboxylic acid amide derivatives | Sankyo Company Limited (JP) | 1990-02-28 | — | — | EP | disclosed |