Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 3/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.44 |
| ▸ | BRS3 | P32247 | 1/20 | 0.41 |
| ▸ | CACNA1G | O43497 | 4/20 | 0.40 |
| ▸ | CACNA1H | O95180 | 4/20 | 0.40 |
| ▸ | CACNA1I | Q9P0X4 | 4/20 | 0.40 |
| ▸ | BRD4 | O60885 | 3/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | TEAD1 | P28347 | 3/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.34 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8563917 | 1.00 | MTNR1A (0.44) | MTNR1AMTNR1BBRS3CACNA1GCACNA1H | |
| SCHEMBL9383838 | 0.84 | TSHR (0.47) | — | |
| SCHEMBL8563258 | 0.75 | MTNR1A (0.54) | MTNR1AMTNR1BBRS3CACNA1GCACNA1H | |
| SCHEMBL8563269 | 0.75 | MTNR1A (0.54) | MTNR1AMTNR1BBRS3CACNA1GCACNA1H | |
| SCHEMBL8563261 | 0.75 | MTNR1A (0.54) | MTNR1AMTNR1BBRS3CACNA1GCACNA1H | |
| SCHEMBL8563264 | 0.75 | MTNR1A (0.54) | MTNR1AMTNR1BBRS3CACNA1GCACNA1H | |
| SCHEMBL15530670 | 0.73 | RORC (0.48) | — | |
| SCHEMBL25740830 | 0.70 | MTNR1A (0.56) | MTNR1AMTNR1BBRS3CACNA1GCACNA1H | |
| SCHEMBL9386737 | 0.68 | ACE (0.36) | BRS3BRD4 | |
| SCHEMBL8563680 | 0.68 | MTNR1A (0.60) | MTNR1AMTNR1BBRS3CACNA1GCACNA1H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719141-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |