Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.74 |
| ▸ | NPC1 | O15118 | 3/20 | 0.74 |
| ▸ | HTT | P42858 | 5/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.70 |
| ▸ | MAPT | P10636 | 4/20 | 0.64 |
| ▸ | BLM | P54132 | 4/20 | 0.61 |
| ▸ | MEN1 | O00255 | 4/20 | 0.61 |
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | CA1 | P00915 | 2/20 | 0.61 |
| ▸ | CA2 | P00918 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.61 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.61 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.61 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.61 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8563248 | 0.88 | HTT (0.65) | RAB9ANPC1HTTSMN1; SMN2MAPT | |
| SCHEMBL8561139 | 0.87 | HTT (0.67) | RAB9ANPC1HTTSMN1; SMN2MAPT | |
| SCHEMBL11863849 | 0.85 | HTT (0.64) | RAB9ANPC1HTTSMN1; SMN2MAPT | |
| SCHEMBL8569537 | 0.83 | HTT (1.00) | RAB9ANPC1HTTSMN1; SMN2MAPT | |
| SCHEMBL8561964 | 0.82 | HTT (0.75) | RAB9ANPC1HTTSMN1; SMN2MAPT | |
| SCHEMBL11871659 | 0.82 | HTT (0.57) | RAB9ANPC1HTTSMN1; SMN2MAPT | |
| SCHEMBL8559872 | 0.81 | HTT (0.73) | RAB9ANPC1HTTSMN1; SMN2MAPT | |
| SCHEMBL11714626 | 0.80 | RAB9A (0.75) | RAB9ANPC1HTTSMN1; SMN2MAPT | |
| SCHEMBL11865712 | 0.78 | CA1 (0.71) | RAB9ANPC1HTTSMN1; SMN2BLM | |
| SCHEMBL6379151 | 0.78 | TAS1R3 (0.69) | RAB9ANPC1HTTSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5814646-A | TREATING THE PROGRESSION OF ALZHEIMER'S DISEASE, BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 1998-09-29 | — | — | US | disclosed |