Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7895077 | 0.79 | HIF1A (0.41) | HIF1ATSHRALDH1A1MEN1KMT2A | |
| SCHEMBL8569067 | 0.70 | CHEK2 (0.32) | ROCK2GSK3AGSK3BROCK1PRKG1 | |
| SCHEMBL12933384 | 0.66 | TSHR (0.49) | HIF1ATSHRALDH1A1MEN1KMT2A | |
| SCHEMBL19325340 | 0.63 | MEN1 (0.47) | TSHRALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL7887076 | 0.63 | GSK3A (0.43) | TSHRALDH1A1MEN1KMT2AROCK2 | |
| SCHEMBL5545073 | 0.63 | HIF1A (0.55) | HIF1ATSHRALDH1A1MEN1KMT2A | |
| SCHEMBL681502 | 0.63 | ALDH1A1 (0.53) | HIF1ATSHRALDH1A1MEN1KMT2A | |
| SCHEMBL8436952 | 0.61 | CHRM2 (0.53) | HIF1ATSHRALDH1A1MEN1KMT2A | |
| SCHEMBL11619531 | 0.61 | TSHR (0.52) | HIF1ATSHRALDH1A1MEN1KMT2A | |
| SCHEMBL27975799 | 0.61 | CHEK1 (0.41) | TSHRALDH1A1ROCK2GSK3AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934257-A1 | SUBSTITUTED N-ARYLMETHYLAMINO DERIVATIVES OF CYCLOBUTENE-3,4-DIONES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998002413-A1 | SUBSTITUTED N-ARYLMETHYLAMINO DERIVATIVES OF CYCLOBUTENE-3,4-DIONES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-01-22 | — | — | WO | disclosed |