Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA7 | P43166 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.33 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8565474 | 1.00 | CA1 (0.38) | CA1CA2CA7CYP2D6PSEN1 | |
| SCHEMBL8561163 | 0.84 | CA1 (0.36) | CA1CA2CA7CYP2D6PSEN1 | |
| SCHEMBL8561160 | 0.84 | CA1 (0.36) | CA1CA2CA7CYP2D6PSEN1 | |
| SCHEMBL8569503 | 0.80 | CYP2D6 (0.39) | CA1CA2CA7CYP2D6KLK5 | |
| SCHEMBL8569499 | 0.80 | CYP2D6 (0.39) | CA1CA2CA7CYP2D6KLK5 | |
| SCHEMBL8564217 | 0.79 | PPARA (0.45) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8564212 | 0.79 | PPARA (0.45) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8626962 | 0.77 | REN (0.42) | — | |
| SCHEMBL8562274 | 0.74 | CTSK (0.48) | CA1CA2CA7CYP2D6CTSK | |
| SCHEMBL8562271 | 0.74 | CTSK (0.48) | CA1CA2CA7CYP2D6CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719141-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |