Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.60 |
| ▸ | BRAF | P15056 | 3/20 | 0.60 |
| ▸ | KIT | P10721 | 2/20 | 0.60 |
| ▸ | FLT3 | P36888 | 2/20 | 0.60 |
| ▸ | CTSD | P07339 | 1/20 | 0.56 |
| ▸ | TRPV1 | Q8NER1 | 11/20 | 0.53 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA7 | P43166 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8561654 | 0.90 | KDR (0.58) | KDRBRAFKITFLT3CTSD | |
| SCHEMBL8565704 | 0.80 | KDR (0.58) | KDRBRAFKITFLT3CTSD | |
| SCHEMBL19668250 | 0.79 | KDR (0.78) | KDRTRPV1CA1CA2CA7 | |
| SCHEMBL13945948 | 0.77 | KDR (0.60) | KDRBRAFKITFLT3GRM4 | |
| SCHEMBL18615348 | 0.77 | KDR (0.85) | KDRTRPV1GRM4CA1CA2 | |
| SCHEMBL13945850 | 0.77 | KDR (0.69) | KDRBRAFKITFLT3CA7 | |
| SCHEMBL8561054 | 0.76 | CTSD (0.57) | KDRBRAFKITFLT3CTSD | |
| Cloflucarban SCHEMBL119821 | 0.76 | KDR (0.88) | KDRTRPV1CA1CA2CA7 | |
| Cloflucarban SCHEMBL27537485 | 0.76 | KDR (0.88) | KDRTRPV1CA1CA2CA7 | |
| SCHEMBL118026 | 0.76 | KDR (1.00) | KDRTRPV1GRM4CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5814646-A | TREATING THE PROGRESSION OF ALZHEIMER'S DISEASE, BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 1998-09-29 | — | — | US | disclosed |
| US-5624937-A | TREATMENT OF ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY (US) | 1997-04-29 | — | — | US | disclosed |