Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.58 |
| ▸ | BRAF | P15056 | 9/20 | 0.58 |
| ▸ | FLT3 | P36888 | 3/20 | 0.58 |
| ▸ | KIT | P10721 | 2/20 | 0.58 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CTSD | P07339 | 1/20 | 0.43 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8561654 | 0.90 | KDR (0.58) | KDRBRAFFLT3KITEGFR | |
| SCHEMBL8566175 | 0.89 | KDR (0.56) | KDRBRAFFLT3KITEGFR | |
| SCHEMBL8564250 | 0.80 | KDR (0.60) | KDRBRAFFLT3KITCTSD | |
| SCHEMBL8563315 | 0.79 | KDR (0.51) | KDRBRAFFLT3KITEGFR | |
| SCHEMBL8562462 | 0.78 | KDR (0.54) | KDRBRAFFLT3KITEGFR | |
| SCHEMBL4555515 | 0.78 | LMNA (0.68) | KDRBRAFFLT3KITLMNA | |
| SCHEMBL8562560 | 0.78 | BRAF (0.64) | KDRBRAFFLT3KITEGFR | |
| SCHEMBL8563685 | 0.78 | KDR (0.54) | KDRBRAFFLT3KITEGFR | |
| SCHEMBL8561054 | 0.76 | CTSD (0.57) | KDRBRAFFLT3KITLMNA | |
| SCHEMBL8562810 | 0.76 | KDR (0.57) | KDRBRAFFLT3KITEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5814646-A | TREATING THE PROGRESSION OF ALZHEIMER'S DISEASE, BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 1998-09-29 | — | — | US | disclosed |
| US-5624937-A | TREATMENT OF ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY (US) | 1997-04-29 | — | — | US | disclosed |