Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.43 |
| ▸ | FOS | P01100 | 3/20 | 0.43 |
| ▸ | JUN | P05412 | 3/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.43 |
| ▸ | RELA | Q04206 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ATF1 | P18846 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | PDE6D | O43924 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8568056 | 0.87 | KDM4E (0.49) | KMT2AMEN1KDM4ENFKB1FOS | |
| SCHEMBL2022576 | 0.84 | KMT2A (0.60) | KMT2AMEN1KDM4EALDH1A1NPC1 | |
| SCHEMBL9875486 | 0.84 | KMT2A (0.60) | KMT2AMEN1KDM4EALDH1A1NPC1 | |
| SCHEMBL8322999 | 0.81 | KMT2A (0.58) | KMT2AMEN1KDM4EALDH1A1NPC1 | |
| SCHEMBL23144946 | 0.81 | KMT2A (0.57) | KMT2AMEN1KDM4EALDH1A1NPC1 | |
| SCHEMBL29843236 | 0.81 | KMT2A (0.57) | KMT2AMEN1KDM4EALDH1A1NPC1 | |
| SCHEMBL8565871 | 0.77 | PDE4B (0.58) | KMT2AMEN1ALDH1A1HTTMAPT | |
| SCHEMBL9588785 | 0.77 | KDM4E (0.47) | KDM4EALDH1A1LMNAMAPTHPGD | |
| Hydrochloric Acid SCHEMBL8564590 | 0.76 | PDE4B (0.57) | KMT2AMEN1ALDH1A1HTTMAPT | |
| SCHEMBL429137 | 0.76 | PDE5A (0.60) | KMT2AMEN1KDM4ENFKB1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618916-B1 | ANTI-RHEUMATIC NAPHTHYRIDINE DERIVATIVES | KNOLL AG (DE) | 1998-09-23 | — | — | EP | disclosed |
| US-5464781-A | TREATING RHEUMATIC DISEASES | THE BOOTS COMPANY PLC (GB) | 1995-11-07 | — | — | US | disclosed |
| WO-1993013097-A1 | ANTI-RHEUMATIC NAPHTHYRIDINE DERIVATIVES | THE BOOTS COMPANY PLC (GB) | 1993-07-08 | — | — | WO | disclosed |