Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | FOS | P01100 | 3/20 | 0.44 |
| ▸ | JUN | P05412 | 3/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.44 |
| ▸ | RELA | Q04206 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8564446 | 0.87 | KMT2A (0.55) | KDM4EFOSJUNNFKB1NFKB2 | |
| SCHEMBL2650510 | 0.84 | L3MBTL1 (0.36) | KDM4EFOSJUNNFKB1NFKB2 | |
| SCHEMBL1905334 | 0.83 | KMT2A (0.49) | KDM4EKMT2ANPC1RAB9AMEN1 | |
| SCHEMBL8327448 | 0.81 | NPC1 (0.44) | KDM4EKMT2ANPC1RAB9AMEN1 | |
| SCHEMBL9874630 | 0.81 | KMT2A (0.50) | KDM4EKMT2ANPC1RAB9AMEN1 | |
| SCHEMBL29531900 | 0.81 | KDM4E (0.49) | KDM4EFOSJUNNFKB1NFKB2 | |
| SCHEMBL2649173 | 0.80 | TAS2R14 (0.39) | GAATGFBR1 | |
| SCHEMBL23145042 | 0.80 | KMT2A (0.44) | KDM4EKMT2ANPC1RAB9AMEN1 | |
| SCHEMBL1906531 | 0.80 | ALDH1A1 (0.44) | KDM4EKMT2ANPC1RAB9AMEN1 | |
| SCHEMBL29843352 | 0.80 | KMT2A (0.44) | KDM4EKMT2ANPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618916-B1 | ANTI-RHEUMATIC NAPHTHYRIDINE DERIVATIVES | KNOLL AG (DE) | 1998-09-23 | — | — | EP | disclosed |
| US-5464781-A | TREATING RHEUMATIC DISEASES | THE BOOTS COMPANY PLC (GB) | 1995-11-07 | — | — | US | disclosed |
| WO-1993013097-A1 | ANTI-RHEUMATIC NAPHTHYRIDINE DERIVATIVES | THE BOOTS COMPANY PLC (GB) | 1993-07-08 | — | — | WO | disclosed |