Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.49 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8560716 | 0.85 | TSHR (0.49) | CYP1A2KDM4EKMT2ASMN1; SMN2PDGFRB | |
| SCHEMBL13302131 | 0.82 | RAB9A (0.55) | CYP1A2KDM4EKMT2ASMN1; SMN2PDGFRB | |
| SCHEMBL621584 | 0.82 | CYP1A2 (0.57) | CYP1A2KDM4EKMT2ASMN1; SMN2PDGFRB | |
| SCHEMBL8566047 | 0.79 | TLR8 (0.54) | CYP1A2KDM4EKMT2ASMN1; SMN2PDGFRB | |
| SCHEMBL28284739 | 0.79 | PDGFRB (0.51) | CYP1A2KDM4EKMT2ASMN1; SMN2PDGFRB | |
| SCHEMBL28028944 | 0.79 | PDGFRB (0.51) | CYP1A2KDM4EKMT2ASMN1; SMN2PDGFRB | |
| SCHEMBL272613 | 0.79 | PDGFRB (0.51) | CYP1A2KDM4EKMT2ASMN1; SMN2PDGFRB | |
| SCHEMBL28286268 | 0.79 | PDGFRB (0.51) | CYP1A2KDM4EKMT2ASMN1; SMN2PDGFRB | |
| SCHEMBL16836341 | 0.78 | RAB9A (0.57) | CYP1A2KDM4EKMT2ASMN1; SMN2PDGFRB | |
| SCHEMBL16836398 | 0.78 | TLR8 (0.55) | CYP1A2KDM4EKMT2ASMN1; SMN2PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719141-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |
| CN-1169986-A | 2.9-diamino-and 2-amino-8-carbamoyl-4-hydroxy-aldanoic acid amide derivatives | CIBA GEIGY AG (CH) | 1998-01-14 | — | — | CN | disclosed |
| EP-0702004-A2 | 2,9-diamino- and 2-amino-8-carbamoyl-4-hydroxy-alkanoic acid amid derivatives | CIBA-GEIGY AG (CH) | 1996-03-20 | — | — | EP | disclosed |