SCHEMBL8564543

SCHEMBL8564543

CCCCCc1cccc(CC(C)=CCS)c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LPL P06858 3/20 0.48
LIPG Q9Y5X9 3/20 0.48
PPARA Q07869 3/20 0.41
PPARG P37231 3/20 0.41
GPR84 Q9NQS5 2/20 0.41
TRPA1 O75762 1/20 0.39
INHA P05111 1/20 0.39
CNR1 P21554 1/20 0.39
SLC6A2 P23975 1/20 0.39
HTR2A P28223 1/20 0.39
SLC6A4 P31645 1/20 0.39
CNR2 P34972 1/20 0.39
OPRM1 P35372 1/20 0.39
SLC6A3 Q01959 1/20 0.39
KCNH2 Q12809 1/20 0.39
TRPM8 Q7Z2W7 1/20 0.39
TRPV1 Q8NER1 1/20 0.39
TRPV3 Q8NET8 1/20 0.39
TRPV4 Q9HBA0 1/20 0.39
TRPV2 Q9Y5S1 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8560064 0.99 LPL (0.49) LPLLIPGPPARAPPARGGPR84
SCHEMBL8564066 0.95 LPL (0.42) LPLLIPGPPARAPPARG
SCHEMBL8565356 0.89 CNR1 (0.36) LPLLIPGCNR1CNR2OPRM1
SCHEMBL8566370 0.83 BCL2 (0.35) TRPA1
SCHEMBL8518305 0.77 LPL (0.66) LPLLIPGPPARAPPARGSLC6A2
SCHEMBL2617117 0.76 GPR84 (0.54) LPLLIPGPPARAPPARGGPR84
SCHEMBL9007016 0.75 TAAR1 (0.41)
SCHEMBL6932623 0.75 LPL (0.67) LPLLIPGPPARAPPARGSLC6A2
SCHEMBL5249436 0.75 LPL (0.67) LPLLIPGPPARAPPARGSLC6A2
SCHEMBL4032533 0.75 LPL (0.67) LPLLIPGPPARAPPARGSLC6A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5717094-A 6-THIOCHROMANYL-ETHYNE, 6-CHROMANYL ETHYNE AND 6-TETRAHYDROQUINOLINYL ETHYNE OR THEIR METAL SALTS ARE REACTED WITH SUITABLE HALO SUBSTITUTED PHENYL OR HETEROARYL COMPUNDS ALLERGAN (US) 1998-02-10 US disclosed
US-5248777-A Inhibitors of ornithine decarboxylase ALLERGAN, INC. (US) 1993-09-28 US disclosed
EP-0290130-B1 ACETYLENES DISUBSTITUTED WITH A PHENYL GROUP AND A HETEROBICYCLIC GROUP HAVING RETINOID LIKE ACTIVITY ALLERGAN, INC (US) 1991-11-06 EP disclosed
US-5053523-A Chemical intermediate for compounds having retinoic acid-like activity ALLERGAN, INC. (US) 1991-10-01 US disclosed
US-5023341-A Acetylene thiochroman ALLERGAN, INC. (US) 1991-06-11 US disclosed
EP-0419132-A2 Process and intermediates for preparing compounds having a disubstituted acetylene moiety and retinoic acid-like biological activity ALLERGAN, INC. (US) 1991-03-27 EP disclosed
US-4810804-A PSORIASIS ALLERGAN, INC. (US) 1989-03-07 US disclosed
EP-0290130-A1 Acetylenes disubstituted with a phenyl group and a heterobicyclic group having retinoid like activity ALLERGAN, INC (US) 1988-11-09 EP disclosed