Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 3/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8564565 | 1.00 | MTNR1A (0.47) | MTNR1AMTNR1BEPHX2BRD4CREBBP | |
| SCHEMBL8564560 | 1.00 | MTNR1A (0.47) | MTNR1AMTNR1BEPHX2BRD4CREBBP | |
| SCHEMBL8563961 | 0.83 | MTNR1A (0.46) | MTNR1AMTNR1BEPHX2BRD4CREBBP | |
| SCHEMBL8563958 | 0.83 | MTNR1A (0.46) | MTNR1AMTNR1BEPHX2BRD4CREBBP | |
| SCHEMBL8563956 | 0.83 | MTNR1A (0.46) | MTNR1AMTNR1BEPHX2BRD4CREBBP | |
| SCHEMBL20609826 | 0.80 | MTNR1A (0.42) | MTNR1AMTNR1BEPHX2BRD4CREBBP | |
| SCHEMBL7422364 | 0.73 | MTNR1A (0.59) | MTNR1AMTNR1BEPHX2BRD4CREBBP | |
| SCHEMBL7422361 | 0.73 | MTNR1A (0.59) | MTNR1AMTNR1BEPHX2BRD4CREBBP | |
| SCHEMBL9965445 | 0.70 | BRD4 (0.55) | MTNR1AMTNR1BEPHX2BRD4CREBBP | |
| SCHEMBL2620988 | 0.70 | BRD4 (0.55) | MTNR1AMTNR1BEPHX2BRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719141-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |
| EP-0702004-A2 | 2,9-diamino- and 2-amino-8-carbamoyl-4-hydroxy-alkanoic acid amid derivatives | CIBA-GEIGY AG (CH) | 1996-03-20 | — | — | EP | disclosed |