Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 10/20 | 0.77 |
| ▸ | HTR3B | O95264 | 10/20 | 0.77 |
| ▸ | HTR3A | P46098 | 10/20 | 0.77 |
| ▸ | HTR3D | Q70Z44 | 10/20 | 0.77 |
| ▸ | HTR3C | Q8WXA8 | 10/20 | 0.77 |
| ▸ | HTR1A | P08908 | 9/20 | 0.77 |
| ▸ | HTR2C | P28335 | 7/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8563750 | 0.87 | HTR3E (1.00) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL8878952 | 0.86 | HTR3E (0.77) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL8880167 | 0.86 | HTR1A (0.79) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL8570057 | 0.85 | HTR3E (1.00) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7305355 | 0.84 | HTR1A (1.00) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7306555 | 0.83 | HTR1A (1.00) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL8565130 | 0.81 | HTR3E (0.76) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL8566281 | 0.81 | HTR3E (1.00) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL8569339 | 0.81 | HTR3E (1.00) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL8565010 | 0.78 | HTR3E (0.84) | HTR3EHTR3BHTR3AHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0623620-B1 | 5-HT3 Pyrrolopyrazine derivatives | ADIR (FR) | 1998-09-09 | — | — | EP | disclosed |
| US-5599812-A | ANTISEROTONINE AGENTS | ADIR ET COMPAGNIE (FR) | 1997-02-04 | — | — | US | disclosed |
| EP-0623620-A1 | 5-HT3 Pyrrolopyrazine derivatives | ADIR ET COMPAGNIE (FR) | 1994-11-09 | — | — | EP | disclosed |