Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 3/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.31 |
| ▸ | HRH2 | P25021 | 1/20 | 0.31 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8565563 | 0.87 | INSR (0.34) | TMEM97SIGMAR1LMNAHRH3SMN1; SMN2 | |
| SCHEMBL8567149 | 0.82 | ESR1 (0.38) | ESR1ESR2TMEM97SIGMAR1PDE4B | |
| SCHEMBL8563251 | 0.74 | ESR1 (0.39) | ESR1ESR2TMEM97SIGMAR1PDE4B | |
| SCHEMBL8567196 | 0.74 | ESR1 (0.39) | ESR1ESR2TMEM97SIGMAR1PDE4B | |
| SCHEMBL8559448 | 0.74 | ESR1 (0.39) | ESR1ESR2TMEM97SIGMAR1PDE4B | |
| SCHEMBL8559207 | 0.73 | MAPT (0.43) | ESR1ESR2SMN1; SMN2 | |
| SCHEMBL8559199 | 0.73 | ESR1 (0.39) | ESR1ESR2PDE4BPDE4DBACE1 | |
| SCHEMBL8563245 | 0.73 | ESR1 (0.38) | ESR1ESR2TMEM97SIGMAR1PDE4B | |
| SCHEMBL8567192 | 0.72 | ESR1 (0.37) | ESR1ESR2TMEM97SIGMAR1PDE4B | |
| SCHEMBL8562057 | 0.71 | ESR1 (0.38) | ESR1ESR2TMEM97SIGMAR1PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5827849-A | HAVING INHIBITORY EFFECT ON INFLAMMATION AND BONE DEGRADATION, ANTITHROMBOTIC, ANTIAGGREGATORY AND TUMOR- OR METASTASIS-INHIBITING EFFECT | KARL THOMAE GMBH (DE) | 1998-10-27 | — | — | US | disclosed |