Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 10/20 | 1.00 |
| ▸ | HTR3B | O95264 | 10/20 | 1.00 |
| ▸ | HTR3A | P46098 | 10/20 | 1.00 |
| ▸ | HTR3D | Q70Z44 | 10/20 | 1.00 |
| ▸ | HTR3C | Q8WXA8 | 10/20 | 1.00 |
| ▸ | HTR1A | P08908 | 9/20 | 1.00 |
| ▸ | HTR2C | P28335 | 9/20 | 1.00 |
| ▸ | HTR1D | P28221 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8563997 | 0.88 | HTR3E (0.78) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL8562660 | 0.84 | HTR3E (1.00) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL8570428 | 0.84 | HTR3E (0.73) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL8569694 | 0.84 | HTR3E (0.75) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL8564159 | 0.83 | HTR3E (1.00) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL8561755 | 0.80 | HTR3E (0.80) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL8565062 | 0.79 | HTR3E (0.71) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL8566532 | 0.79 | HTR3E (0.76) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL8567602 | 0.78 | HTR1A (1.00) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL8565127 | 0.78 | HTR3E (1.00) | HTR3EHTR3BHTR3AHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0623620-B1 | 5-HT3 Pyrrolopyrazine derivatives | ADIR (FR) | 1998-09-09 | — | — | EP | claimed |
| EP-0623620-A1 | 5-HT3 Pyrrolopyrazine derivatives | ADIR ET COMPAGNIE (FR) | 1994-11-09 | — | — | EP | claimed |
| EP-0623620-B1 | 5-HT3 Pyrrolopyrazine derivatives | ADIR (FR) | 1998-09-09 | — | — | EP | disclosed |
| US-5599812-A | ANTISEROTONINE AGENTS | ADIR ET COMPAGNIE (FR) | 1997-02-04 | — | — | US | disclosed |
| EP-0623620-A1 | 5-HT3 Pyrrolopyrazine derivatives | ADIR ET COMPAGNIE (FR) | 1994-11-09 | — | — | EP | disclosed |