SCHEMBL8565043

SCHEMBL8565043

CC(=O)NCC(=O)Nc1ccc(C=CC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cc1

nearest known ligand 0.91

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
BDKRB2 P30411 20/20 0.91

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8565041 1.00 BDKRB2 (0.91) BDKRB2
Hydrochloric Acid SCHEMBL8563027 0.99 BDKRB2 (0.92) BDKRB2
Hydrochloric Acid SCHEMBL8563030 0.99 BDKRB2 (0.92) BDKRB2
SCHEMBL8562460 0.95 BDKRB2 (1.00) BDKRB2
SCHEMBL8562465 0.95 BDKRB2 (1.00) BDKRB2
SCHEMBL8560900 0.94 BDKRB2 (0.88) BDKRB2
SCHEMBL8561929 0.94 BDKRB2 (0.88) BDKRB2
SCHEMBL8561926 0.94 BDKRB2 (0.88) BDKRB2
SCHEMBL8567137 0.94 BDKRB2 (0.87) BDKRB2
SCHEMBL8567134 0.94 BDKRB2 (0.87) BDKRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0596406-B1 Imidazo (1,2-a) Pyridines as bradykinin antagonists FUJISAWA PHARMACEUTICAL CO (JP) 1998-12-16 EP disclosed
US-5574042-A ANTAGONIST FOR BRADYKININS AS ANTIALLERGENS, AUTOIMMUNE DISEASES, ANTIINFLAMMATORY AGENTS, SHOCK OR PAIN FUJISAWA PHARMACEUTICAL CO., LTD (JP) 1996-11-12 US disclosed
EP-0596406-A1 Imidazo (1,2-a) Pyridines as bradykinin antagonists FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1994-05-11 EP disclosed