Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 6/20 | 0.42 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8559696 | 0.91 | KDM4E (0.41) | MAPTLMNAALDH1A1KDM4EHPGD | |
| SCHEMBL9542072 | 0.88 | PDE4B (0.43) | MAPTLMNAALDH1A1NPSR1GAA | |
| SCHEMBL8563378 | 0.80 | PDE4B (0.59) | MAPTALDH1A1NPSR1GAASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL811230 | 0.79 | PDE4B (0.58) | MAPTALDH1A1NPSR1GAASMN1; SMN2 | |
| SCHEMBL8322260 | 0.77 | DPP4 (0.48) | DPP4MAPTKDM4ENPSR1NPC1 | |
| SCHEMBL8562110 | 0.76 | MAPT (0.56) | MAPTLMNAALDH1A1KDM4EHPGD | |
| Hydrochloric Acid SCHEMBL8566639 | 0.75 | MAPT (0.55) | MAPTLMNAALDH1A1KDM4EHPGD | |
| SCHEMBL8327645 | 0.74 | KMT2A (0.51) | DPP4MAPTALDH1A1KDM4EHPGD | |
| SCHEMBL8558688 | 0.74 | PDE4B (0.60) | MAPTALDH1A1NPSR1GAASMN1; SMN2 | |
| SCHEMBL8569260 | 0.74 | PDE4B (0.56) | MAPTLMNAALDH1A1NPSR1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618916-B1 | ANTI-RHEUMATIC NAPHTHYRIDINE DERIVATIVES | KNOLL AG (DE) | 1998-09-23 | — | — | EP | disclosed |
| US-5464781-A | TREATING RHEUMATIC DISEASES | THE BOOTS COMPANY PLC (GB) | 1995-11-07 | — | — | US | disclosed |
| EP-0618916-A1 | ANTI-RHEUMATIC NAPHTHYRIDINE DERIVATIVES | Knoll AG (DE) | 1994-10-12 | — | — | EP | disclosed |
| WO-1993013097-A1 | ANTI-RHEUMATIC NAPHTHYRIDINE DERIVATIVES | THE BOOTS COMPANY PLC (GB) | 1993-07-08 | — | — | WO | disclosed |